23 citations
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November 2021 in “Journal of Bionic Engineering” This study found that PCL-Col/ZnO fibrous scaffolds enhanced wound healing and exhibited antibacterial properties, making them promising for use as a wound dressing.
2 citations
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October 2025 in “Journal of Materials Science Materials in Medicine” In this study, researchers developed a novel zinc oxide nanoflower-infused nanocomposite that demonstrated promising results in accelerating wound healing in a murine model, with enhanced angiogenesis, reduced inflammation, and improved collagen deposition compared to a control group.
2 citations
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September 2023 in “Scientific reports” This study reports that zinc oxide or silver nanoparticles capped with vitamin A or E, incorporated into wheat gluten films, showed significant potential in promoting burn wound healing in mice by facilitating wound contraction, re-epithelialization, and collagen deposition, while also exhibiting antioxidant and antibacterial properties.
January 2026 in “Nanoscale Advances” In this study, a biocompatible zinc oxide nanocomposite loaded with the anticancer drug 9-Br-Nos demonstrated effective drug delivery and cytotoxicity against lung cancer cells in vitro, while also proving non-toxic to healthy cells, suggesting its potential for targeted lung cancer treatment.
September 2025 in “Cell Biochemistry and Function” In this study, ZnO nanoparticles synthesized with Ferulago angulata extract and doped with magnesium showed improved antioxidant, antibacterial, and antifungal properties, and facilitated faster wound healing and hair growth in a burn treatment model, although higher concentrations decreased cell viability.
December 2024 in “Mağallaẗ ʻulūm al-rāfidayn” In this study, zinc oxide nanoparticles were synthesized using a sustainable method from the Lepidium sativum L. plant, and incorporating these nanoparticles into Sunblock Lotion significantly increased its sun protection factor.
September 2025 in “Al-Nahrain Journal of Science” In this research, the authors found that green-synthesized zinc oxide nanoparticles (GS-ZnONPs) exhibited antibacterial activity against Staphylococcus species isolated from alopecia patients, but also showed cytotoxic effects on human dermal fibroblast cells at a 400 mg/mL concentration.
46 citations
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March 2017 in “Nanotoxicology” This study found that topical application of nano-Zinc oxide in newborn mice led to the accumulation of nanoparticles within hair follicles, inducing apoptosis of hair follicle stem cells and potentially disrupting skin homeostasis.
22 citations
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September 2019 in “ACS omega” This study found that AGO@HPC nanocomposite films demonstrated enhanced mechanical, anti-ultraviolet, and antibacterial properties, suggesting potential for use in antibacterial packaging and wound-dressing applications.
2 citations
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December 2025 in “Gels” This study developed a biomimetic 3D skin model with vascularization potential to assess the impact of nano-zinc oxide (nano-ZnO), finding that nano-ZnO significantly influenced genes related to apoptosis, inflammation, and oxidative stress in skin cells.
January 2026 in “Journal of Emerging Technologies and Innovative Research” This study reported that zinc oxide nanoparticles synthesized using Tridax procumbens leaf extract demonstrated significant antibacterial and anticancer activity, showing potential for applications in biomedical and pharmaceutical fields.
This study found that topically applied nano-Zinc oxide accumulated in hair follicles and induced apoptosis in hair follicle stem cells, indicating a potential risk to skin homeostasis.
264 citations
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January 2008 in “Journal of biomedical optics” This study found that ZnO nanoparticles in topical skin products do not penetrate beyond the outer skin layers in humans, suggesting minimal safety concerns for subdermal absorption.
227 citations
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December 2021 in “ACS Nano” This review discussed the potential of multifunctional photoresponsive hydrogels for wound regeneration, highlighting various types prepared with diverse photosensitizers and photothermal/photodynamic agents, and explored their role in modulating bacterial microenvironments to inhibit infection and promote healing.
62 citations
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October 2010 in “Journal of biomedical nanotechnology” This review discusses the challenges and contradictions in understanding nanoparticle penetration and toxicity in human skin, emphasizing the need for standardized testing and further research on particles smaller than 10 nm.
60 citations
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January 2014 in “Anais Brasileiros De Dermatologia” This article discusses the foundational concepts of nanotechnology and its contributions to dermatology and medicine, but does not present new research findings.
49 citations
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January 1991 in “Food and chemical toxicology” In this study, zinc chloride was found to be severely irritant to the skin in rabbit, guinea-pig, and mouse models, while zinc oxide, zinc sulphate, zinc pyrithione, and zinc undecylenate showed minimal to no irritancy.
48 citations
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March 2022 in “Nano Letters” This study suggests that sericin microneedles with antibacterial and directional traction functionalities may enhance infected wound healing by improving skin repair and inhibiting bacterial growth, indicating potential for clinical application.
18 citations
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May 2014 in “International journal of pharmaceutics” This study found that UVA and UVB exposure increased hydroquinone and sunscreen absorption in nude mouse skin, with less absorption enhancement observed in more lipophilic sunscreens.
12 citations
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June 2020 in “Crystals” This study presents a modified method for synthesizing ~1 nm zinc oxide nanoparticles within the pores of SBA-11, maintaining the mesoporous structure without requiring alcohol reflux or basic solution reaction steps.
5 citations
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October 2022 in “Materials Research Express” This study found that zinc oxide and fucoidan-loaded chitosan nanofiber scaffolds may enhance wound healing and provide antibacterial protection against common surgical pathogens in vitro.
4 citations
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December 2022 in “International Journal of Molecular Sciences” This review discusses the role of zinc and its transporters in skin health and disorders, providing an overview without presenting new clinical results.
1 citations
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October 2022 in “Surface Engineering and Applied Electrochemistry” This study reported that zinc nanoparticles synthesized from Monotheca buxifolia leaf extract demonstrated significant antimicrobial, antioxidant, and moderate hair growth-promoting activities, with potential use as a bacterial biosensor.
February 2025 in “The Egyptian Journal of Medical Microbiology” In this study, zinc oxide nanoparticles combined with Carbomer940 hydrogel significantly accelerated wound healing and hair growth in Balb/c mice, showing a 56.9% increase in wound closure rate compared to MEBO ointment and control groups, without causing damage or infection.
September 2022 in “The American journal of dermatopathology/American journal of dermatopathology” In this pilot study, researchers found no sunscreen particles in the hair follicle units of patients with frontal fibrosing alopecia, suggesting no direct link between sunscreen use and the condition.
November 2023 in “Journal of Basic Microbiology” This study explored the fungal diversity on human scalps, identifying 15 genera and 24 species from 18 scalp samples of girls, with yeast-like structures found in 33.3% of cases. Additionally, zinc oxide nanoparticles, synthesized using ginger extract, showed significant antifungal activity against specific species.
In this study, researchers developed a novel gel formulation combining zinc oxide nanoparticles and finasteride-loaded nanostructured lipid carriers, which showed promising results for topical delivery and effective skin penetration, potentially offering a new treatment approach for androgenic alopecia.
January 2022 in “OPAL (Open@LaTrobe) (La Trobe University)” This study used advanced optical imaging techniques to investigate nanoparticle and dye penetration in human skin, finding that nanoparticles mainly resided in the stratum corneum and accumulated in skin folds and hair follicles, while highlighting that sunscreen-based nanoparticles appear unlikely to pose safety concerns.
In this study, formulations containing 20% zinc oxide nanoparticles demonstrated stability and improved spreadability without penetrating the deepest skin layers, instead accumulating in skin furrows and hair follicles.
11 citations
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November 2003 in “PubMed” This study found that hair luster increased with higher fiber pigmentation and application of specific cosmetic oils and styling resins, while micronized ZnO and synthetic sebum dulled hair.