Synergistic Antibacterial Activity and Wound Healing Properties of Selenium-Chitosan-Mupirocin Nanohybrid System: An In Vivo Study on Rat Diabetic Staphylococcus Aureus Wound Infection Model

    February 2020 in “ Scientific reports ”
    Reza Golmohammadi, Shahin Najar Peerayeh, Tahereh Tohidi Moghadam, Seyed Mohammad Hosseini
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    TLDR The nanohybrid system significantly improved wound healing and showed strong antibacterial activity.
    The study formulated a Selenium-Chitosan-Mupirocin (M-SeNPs-CCH) nanohybrid system using a chitosan-cetyltrimethylammonium bromide-based hydrogel to treat mupirocin-methicillin-resistant Staphylococcus aureus (MMRSA) infections in a rat diabetic wound model. The system, applied twice daily for 21 days, significantly improved wound healing, as evidenced by wound contraction and histopathological changes, compared to control groups (P ≤ 0.05). The nanohybrid system demonstrated synergistic antibacterial activity, reducing the minimum inhibitory concentration of mupirocin threefold, and promoted angiogenesis, fibroblastosis, collagenesis, hair follicle proliferation, and epidermis growth. This suggests potential for treating mild-stage diabetic wound infections.
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