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research MicroRNA control of signal transduction

1066 citations , March 2010 in “Nature Reviews Molecular Cell Biology”

This review discusses the potential regulation of signal transduction pathways by microRNAs in animal cells, aiming to identify biological processes that may be influenced by miRNA-mediated regulation, but it reports no new experimental outcomes.

research Mice with a null mutation of the TGFα gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation

578 citations , April 1993 in “Cell”

This study found that mice with a disrupted TGFα gene display a curly whisker-coat phenotype, similar to waved-1 mice, suggesting TGFα's crucial role in skin architecture and hair development.

research Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice¹

519 citations , October 1998 in “Endocrinology”

The study found that normalizing mineral ion levels in vitamin D receptor-ablated mice prevented hyperparathyroidism and bone disorders but did not address hair loss, indicating the VDR's role in hair growth.

research The microbiome in patients with atopic dermatitis

365 citations , November 2018 in “Journal of Allergy and Clinical Immunology”

This review discusses the role of the skin microbiome in maintaining health and modulating atopic dermatitis, emphasizing the need for novel therapeutic strategies, but reports no new clinical results.

research Penetration Profile of Microspheres in Follicular Targeting of Terminal Hair Follicles

316 citations , June 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that using a standardized protocol with microspheres of approximately 1.5 micrometers enhances penetration into hair follicles, particularly when skin is treated with cyanoacrylate skin surface stripping.

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Community Join

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community Microneedling + topical minoxidil is the most underrated combo.

439 upvotes 1 year ago

Microneedling with topical minoxidil is effective for hair regrowth, especially with finasteride. Users report fewer side effects compared to oral minoxidil.

community microneedling recommendations?

1 upvotes 3 days ago

For microneedling, users recommend using a stamp or dermapen, with options like the M8 or A6 being affordable. The Derminator 2 is noted as a more expensive, medical-grade option.

community Losing Hair from Microneedling?

4 upvotes 4 days ago

Microneedling can cause hair shedding due to follicle puncturing, especially when using a 1mm depth. Users suggest using a dermastamp with a depth of 0.6-1mm and caution against home microneedling to avoid damaging hair follicles.

community How often should I microneedle. And what length?

2 upvotes 1 week ago

Microneedling for hair loss involves using 0.25-0.5mm needles multiple times a week for Minoxidil absorption and 1.0-1.5mm needles once every two weeks to a month for deep follicle stimulation. One user prefers using 1.5mm needles every two weeks, separate from Minoxidil application days.

community Microneedling / dermastamp depth recommendations?

3 upvotes 1 week ago

Microneedling with a 0.6mm depth, combined with minoxidil application, has shown impressive hair regrowth for some users, despite concerns about safety and potential side effects. Users report varying practices, with some applying minoxidil immediately after microneedling and others advising against it.

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