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Research

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research Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

665 citations , April 2016 in “Nature communications”

This study shows that inhibiting anti-apoptotic proteins BCL-W and BCL-XL can specifically induce apoptosis in senescent cells, suggesting a potential strategy for treating age-related pathologies.

research Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts

133 citations , November 2018 in “Aging”

This study identified Azithromycin and Roxithromycin as novel senolytic antibiotics that effectively target and reduce senescent human fibroblast cells.

research Oxidative Stress–Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia

93 citations , February 2015 in “Journal of Investigative Dermatology”

This study suggests that oxidative stress may contribute to androgenetic alopecia by inducing premature senescence and secretion of hair growth inhibitors in dermal papilla cells from balding scalp.

research Anti-ageing effect of a lactococcal strain: analysis using senescence-accelerated mice

87 citations , July 2007 in “British Journal Of Nutrition”

In this study, oral administration of Lactococcus lactis strain H61 to senescence-accelerated mice was linked to reduced bone density loss, less skin ulcer incidence, and reduced hair loss, along with altered immune responses.

research The Senescence–Stemness Alliance – A Cancer-Hijacked Regeneration Principle

68 citations , September 2018 in “Trends in Cell Biology”

This review discusses the senescence–stemness connection in cellular biology and reports no new findings, highlighting implications for both tissue repair and aggressive cancer behavior.

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Community Join

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community Sensitive liver, topical fin safe to try?

in Finasteride 98 upvotes 1 year ago

Topical finasteride is considered safer for the liver than oral finasteride due to less systemic absorption, but regular liver function tests are advised. The user is concerned about liver health due to a history of NAFLD and is exploring topical finasteride as a safer alternative.

community Burning sensation and acne along temples accompanied by aggressive recession. On 0.5mg dut, 1.25mg fin EOD, and oral min 5mg daily.

in Finasteride/Dutasteride 2 upvotes 1 year ago

The user experienced temple recession, shedding, and acne while on 0.5mg dutasteride, 1.25mg finasteride every other day, and 5mg oral minoxidil daily. They are considering switching treatments due to worsening symptoms and are contemplating using a topical anti-androgen like RU58841.

community Cell senescence-targeted treatment for hair loss, has anyone tried any products/enzymes etc. that use this theory

5 upvotes 1 year ago

DHT causes hair loss by driving cells into senescence, and a polyphenol in black chokeberry may reverse this. A product using this theory is being considered for use alongside finasteride, minoxidil, and microneedling.

community Desensitize Follicle Sensitivity to DHT?

12 upvotes 1 month ago

Hair follicles cannot be desensitized to DHT like allergies; treatments focus on reducing DHT levels or blocking its effects using methods like finasteride, GT20029, or PROTACs. Topical treatments like ceterizine and BPA application are also mentioned.

community Topicals for sensitive scalp (+sed derm)

9 upvotes 2 months ago

The conversation is about finding a gentle topical treatment for a sensitive scalp with seborrheic dermatitis. Suggestions include using Trichosol/Trichofoam-based topical finasteride/minoxidil, which is considered gentle on the scalp.

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Learn

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learn Centella

Hormone-related scalp sensitivity: is there evidence for a centella mask? Centella asiatica has anti-inflammatory and wound-healing effects in animal and cell studies, but no published research has tested a centella scalp mask on the human scalp, in hormonal contexts or otherwise, and no community reports were found of one being used this way.

learn capsicum

Is capsicum safe for sensitive scalps or inflammatory hair loss? Capsicum may irritate sensitive scalps and worsen inflammatory hair loss.

learn Scalp Micropigmentation

Is scalp micropigmentation suitable for people with sensitive skin? Providers say scalp micropigmentation suits most skin types and describe patch tests, hypoallergenic pigments and a skin consultation for sensitive skin. These are provider claims rather than independent safety evidence, and pigment reactions remain a risk.

learn Ecklonia Cava

Is Ecklonia Cava safe for sensitive or irritated scalps? No published study has tested Ecklonia cava on sensitive or irritated human scalps. Any botanical extract can cause irritation or allergy, so patch-test first and stop if irritation occurs.

learn Hair Fibers

Are hair fibers safe for sensitive scalps or people with dandruff and irritation? No study has tested hair fibers on sensitive or dandruff-prone scalps. Users are advised to wash them out daily, try a small area first, and stop if irritation appears.

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