612 citations
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February 2004 in “Nature” This study found that the OXI1 gene in Arabidopsis thaliana is vital for activating key protein kinases and is necessary for oxidative burst signal responses like pathogen resistance and root hair growth.
January 2025 in “bioRxiv (Cold Spring Harbor Laboratory)” This study identifies Armadillo Repeat Only proteins as crucial regulators of plant CNGC channels, influencing various plant functions and showcasing a unique plant-specific role in Ca2+ signaling.
1 citations
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January 2006 in “Maia-rivista Di Letterature Classiche” This review discusses the bioactive compounds and biological activities of Polygonum multiflorum Thunb. and highlights concerns about its hepatotoxicity, but reports no new clinical results.
32 citations
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December 2003 in “Planta” This study found that hypaphorine alters cytoskeletal organization in Eucalyptus globulus root hairs, contributing to reduced root hair elongation by possibly disrupting vesicle delivery needed for growth.
December 2020 in “Rev. Amazon.” This study identified that 80% of a rural population in Ecuador uses medicinal plants like Aloe vera for treating hair conditions, highlighting the prevalence of ancestral plant knowledge.
September 2026 in “World Journal of Pharmacy and Pharmaceutical Sciences” In this study, a new hair serum featuring Catharanthus roseus extract was formulated and evaluated, showing a stable and appealing product with potential hair growth-promoting properties, positioning it as a promising herbal alternative to synthetic agents like minoxidil.
80 citations
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November 2017 in “New Phytologist” In this study, the researchers used the dual-flow-RootChip to show that Arabidopsis roots can locally adapt their hair development in response to asymmetric phosphate conditions.
October 2019 in “International Journal of AYUSH Case Reports” This case study reported that a 29-year-old male patient with alopecia areata patchy experienced hair regrowth and relief from scalp itching and dandruff after using medicinal leech therapy and specific internal medicines for three months.
512 citations
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February 2008 in “Science” In this study, researchers found that a positive feedback loop involving Ca 2+ and RHD2 NADPH oxidase-derived ROS helps maintain growth sites, crucial for root hair development and cell shape in Arabidopsis thaliana.
August 2026 in “Revista Brasileira de Farmacognosia” Sea holly extract may help reduce hair loss.
January 2026 in “International Journal of Health Engineering and Technology” In this study, researchers evaluated the effects of green spinach leaf extract on hair growth in New Zealand rabbits and found that the 15% concentration formula resulted in the highest average hair growth compared to other concentrations and controls.
February 2023 in “Clinical Toxicology” This letter to the editor raises concerns about minoxidil, an arterial vasodilator also used for androgenic alopecia, noting that overdose can cause severe side effects such as distributive shock, pulmonary edema, and myocardial ischemia.
This overview discusses the medicinal uses and pharmacological activities of Eclipta alba, yet reports no new experimental findings; it emphasizes the plant's significant role in traditional medicine.
March 2015 in “Daehan boncho haghoeji/Daehan bonchohak hoeji” This study found that HET extract increased dorsal hair density and VEGF protein expression in a hair growth animal model suggesting its potential efficacy for alopecia treatment.
4 citations
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January 2008 in “Food Science and Technology Research” This study found that mature leaves of Japanese 'Saijo' persimmon have the highest ascorbic acid levels, whereas polyphenol levels were high in both mature leaves and adventitious shoots but low in young shoots.
1 citations
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January 2019 in “Journal of pharmacy & pharmacognosy research” This study found that a 2.5% flavonoid-rich extract of Equisetum hyemale promoted hair growth in a rat model of chemically-induced alopecia, showing results comparable to 5% minoxidil.
March 2026 in “International Journal of Science and Research (IJSR)” This research focused on Eclipta prostrata, revealing unique anatomical features and bioactive compounds such as alkaloids and flavonoids that can aid in reliable identification and quality control of this medicinal herb, commonly used for hair growth and liver health.
23 citations
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July 2022 in “Nature Cell Biology” Targeting THY1 can improve skin repair and healing.
56 citations
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March 2017 in “Plant and Cell Physiology” This study used light sheet fluorescence microscopy to successfully image and analyze calcium oscillations in the root hairs of Arabidopsis thaliana, finding that these oscillations correlate with the root hair growth rate and that auxin affects these properties.
49 citations
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October 2014 in “International Scholarly Research Notices” This review explores the medicinal properties of Eclipta alba and its phytoconstituents and reports their potential for developing new drugs, but presents no new research results.
August 2025 in “Tropical Journal of Natural Product Research” This study found that hydromethanolic extracts from Carthamus caeruleus L. rhizomes exhibited notable antioxidant and anti-inflammatory effects in both in vitro and in vivo experiments, supporting its traditional medicinal uses and suggesting its potential as a source of therapeutic agents.
131 citations
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January 2018 in “Scientific Reports” In this study, mycorrhizal fungal inoculation was associated with increased root-hair growth and enhanced drought tolerance in trifoliate orange by modulating auxin synthesis and transport under water stress conditions.
December 2016 in “Chinese Journal of Dermatology” This study found that adenosine can promote the growth of human hair follicles and dermal papilla cell proliferation, possibly through increased angiogenin expression.
December 2021 in “Ad-Dawaa' Journal of Pharmaceutical Sciences” This study concluded that hair tonic formulations using extracts of green tea leaves, celery leaves, or their combination can effectively promote hair growth in guinea pigs, with the fastest growth seen using a 2.5% green tea to 7.5% celery leaf extract ratio.
Low vitamin C caused bleeding and corkscrew hair, resolved with vitamin C treatment.
13 citations
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December 2017 in “Archives of Medical Sciences” This article highlights that rivaroxaban, commonly associated with bleeding risks, may also cause rare non-bleeding adverse effects like liver injury and hypersensitivity.
15 citations
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January 2015 in “Pharmaceutical Biology” In a study on nude mice, topical application of Chrysanthemum zawadskii extracts stimulated hair growth and increased hair follicle numbers, suggesting potential for alopecia therapy.
January 2026 in “Journal of Materials Chemistry B” In this study, researchers addressed the limitations of adenosine's practical application in treating inflammation, oxidative stress, and tissue repair due to its poor water solubility and low transdermal permeability. Results are not reported in the abstract.
January 2020 in “Journal of Medicinal Plants Studies” This review highlights advancements in the cultivation and chemical analysis of Eclipta alba (L.) Hassk., including increased bioactive compounds in induced tetraploids and successful micropropagation techniques, supporting its medicinal use and production efficiency.
October 2025 in “Pharmaceuticals” This review discusses the repurposing of auranofin for oncological and non-oncological uses and highlights its early-stage clinical trial findings, suggesting further exploration of its therapeutic potential.