Promotive Effects of Adenosine on Human Hair Follicle Growth and Angiogenin Expression

The study demonstrated that adenosine promoted the growth of human hair follicles and the proliferation of dermal papilla cells, likely by up-regulating angiogenin expression. Hair follicles treated with 10-1,000 μmol/L adenosine showed significantly increased growth, with 100 μmol/L having the strongest effect. Similarly, adenosine enhanced the proliferative activity of dermal papilla cells, particularly at 10 and 100 μmol/L. The presence of anti-human angiogenin antibody partially antagonized these effects. Additionally, adenosine treatment resulted in lower proportions of cells in the G1 phase and higher proportions in the G2 and S phases, with increased mRNA and protein expressions of angiogenin.