TLDR Rivaroxaban can cause liver injury, allergic reactions, blood vessel inflammation, and hair loss, but these side effects are rare.
The document from 2017 reviewed non-hemorrhage-related adverse effects of rivaroxaban, noting that while bleeding is a well-known side effect, others such as liver injury, hypersensitivity reactions, leukocytoclastic vasculitis, and hair loss are less recognized. Liver injury was seen in 2.33% of patients in phase III studies, but a larger review of 29 trials with 152,116 patients showed no increased risk of liver injury. Hypersensitivity reactions occurred at a rate of 0.1-1% in the ROCKET-AF study, and there were two reported cases of leukocytoclastic vasculitis. Hair loss was reported by 9 out of 730 patients in one study, with an average onset of 68 days after starting rivaroxaban. A specific case of a 26-year-old woman showed hair loss after three months of treatment, which resolved upon discontinuation of the drug. The suspected mechanism for hair loss is telogen effluvium. Clinicians are encouraged to monitor for these rare adverse reactions and to report any unexpected clinical responses.
31 citations,
January 2016 in “Drugs - Real World Outcomes” Some new oral anticoagulants may also cause hair loss and might not be better than traditional ones for preventing hair loss.
8 citations,
August 2015 in “European Journal of Clinical Pharmacology” Rivaroxaban may cause hair loss.
26 citations,
August 2006 in “Journal of Clinical Pharmacy and Therapeutics” Some patients lost hair after being treated with the drug enoxaparin for a brain vein clot.
15 citations,
May 2003 in “American Journal of Kidney Diseases” A hemodialysis patient's hair loss was caused by the drug tinzaparin but stopped after switching to a different drug.
63 citations,
March 1995 in “International Journal of Dermatology” Some drugs can cause hair loss, and stopping these drugs often leads to hair regrowth.
8 citations,
August 2015 in “European Journal of Clinical Pharmacology” Rivaroxaban may cause hair loss.
January 2020 in “Jornal Vascular Brasileiro” Anticoagulant therapy may cause hair loss, especially in women, and stopping the medication can lead to hair regrowth.
31 citations,
January 2016 in “Drugs - Real World Outcomes” Some new oral anticoagulants may also cause hair loss and might not be better than traditional ones for preventing hair loss.
July 2018 in “Elsevier eBooks” Some drugs can cause reversible hair loss, but certain chemotherapy drugs may lead to permanent hair loss; drugs can also change hair color and texture.
7 citations,
May 2017 in “Research and Practice in Thrombosis and Haemostasis” Some blood thinners can cause hair loss, but switching medications can stop it.
