Rivaroxaban-Induced Hair Loss

The document reports a case of severe hair loss in a 26-year-old woman attributed to the use of rivaroxaban, a factor Xa inhibitor anticoagulant. The patient experienced significant hair loss three months after starting rivaroxaban for pulmonary embolism, with no other apparent causes such as physiological stress or family history of alopecia. After discontinuing rivaroxaban, her hair regrowth occurred spontaneously a few months later. The case suggests that rivaroxaban may cause hair loss, an adverse effect not listed in the product's characteristics. The incidence of hair loss with rivaroxaban was reported as 4.4 per 100 patient years in a large monocentric prospective NOAC registry, and additional cases were found in the French Pharmacovigilance Database. Minoxidil treatment showed some efficacy in stopping the hair loss. This side effect could impact patients' quality of life and lead to discontinuation of the medication.