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This review discusses the potential role of extracellular vesicles in modulating hair follicle dynamics and reports no new clinical results; future investigations may inform treatment strategies for skin disorders.

This review highlights that exosome-based therapies show promise for hair regeneration by modulating signaling pathways and enhancing hair follicle regeneration; however, further clinical research is needed due to variability in methods and limited clinical studies.

This review highlights the potential of exosome-based therapies for androgenetic alopecia by modulating key signaling pathways in hair follicles, suggesting a promising treatment option that requires further research to validate long-term safety and efficacy.

This study suggests that ceramide may help maintain hair follicles under stress by modulating growth factor pathways in senescence-induced dermal papilla cells.

This study suggests that synthetic ceramides may promote hair growth by inducing proliferation of human dermal papilla cells through modulation of Wnt/β-catenin and BMP2/4 signaling pathways.

This study found that the dermal papilla of the hair follicle regulates stem cell quiescence and regeneration by modulating Shh and Wnt signaling pathways, highlighting the importance of signaling cross talk in regeneration.

This study found that costunolide promotes hair growth in both lab-cultured human hair follicle cells and in live mice by modulating growth factor pathways.

The researchers reported that conditioned media from deer antler mesenchymal stem cells may enhance hair and skin regeneration by modulating cellular responses through secretory vesicles.

This review suggests that curcumin and piperine may offer a promising multi-target therapeutic approach for alopecia by simultaneously modulating androgenic and inflammatory pathways, though experimental and clinical validation are necessary to confirm their efficacy.

The study found that dermal EZH2 plays a crucial role in coordinating dermal fibroblast differentiation and epidermal development by modulating Wnt/β-catenin and retinoic acid signaling.

This study found that red light at an irradiance of 8 mW/cm² was most effective in promoting growth and modulating signaling pathways in dermal papilla cells treated with dihydrotestosterone, suggesting the need for personalized photobiomodulation treatment approaches for androgenetic alopecia.

This study reported that human umbilical cord mesenchymal stem cell-derived exosomes may promote hair regeneration and thickness in androgenic alopecia by modulating cellular pathways in hair growth, including increasing hair density and diameter, as observed in a mouse model and an exploratory clinical trial.

This article reviews emerging treatments for androgenetic alopecia, including topical 5-alpha-reductase inhibitors and prostaglandin modulators, but reports no clinical results and calls for further efficacy evidence, especially for PRP.

In this experimental study, the researchers observed that Platycladus orientalis leaf extract promoted hair growth by enhancing dermal papilla cell proliferation and increasing growth factor expression, particularly through ACK1 activation and modulation of Wnt/β-catenin signaling pathways in cultured human cells and a 12-week topical application.

This study found that fibroblast growth factor 9, initially secreted by γδ T cells, plays a key role in modulating hair follicle regeneration in mice after skin wounds.

This study found that vitamin A significantly enhanced the proliferation and inhibited apoptosis of rabbit dermal papilla cells under heat stress, likely by modulating miR-195/IGF1 and Wnt10b/β-catenin signaling pathways.

This study suggests that bio-nanovesicles, such as exosomes and microvesicles, may enhance skin and hair follicle regeneration by modulating key signaling pathways, potentially overcoming the limitations of conventional treatments for alopecia and chronic skin diseases.

In this study, hemp seed-derived exosomes (E40) showed potential for counteracting DHT-induced inhibition of feather follicle development in chicken embryos by modulating critical signaling pathways, suggesting a therapeutic approach for alopecia.

This study found that Ageratum conyzoides extract enhanced hair growth in mice and human follicle cells, showing potential for hormonal modulation, pathway activation, and antioxidant protection; however, further clinical studies are needed to confirm efficacy in humans.

This review highlights recent advancements in androgenetic alopecia treatment, focusing on the dysregulated signaling pathways involved in hair follicle regeneration and exploring innovative therapeutic strategies, including small molecule modulators and gene editing technologies, which show promise in preclinical models.

In this study, the researchers reported that Krox20 plays a crucial role in epidermal homeostasis and hair development, influencing stem cell maintenance and cell survival through the modulation of cellular pathways.

This study found that ocu-miR-205 influences hair follicle density in Rex rabbits by promoting dermal papilla cell apoptosis and transforming hair follicles from growth to resting phases through signaling pathway modulation.

This study found that human hematopoietic mesenchymal stem cells increased the viability and migration of human outer root sheath cells in an in vitro alopecia areata model, involving Wnt/β-catenin and JAK/STAT pathways.

This review summarizes the potential of exosome-based therapies as a promising treatment for androgenetic alopecia, emphasizing their role in modulating key signaling pathways, but highlights the need for further evidence to confirm their efficacy and safety.

This study investigated a new treatment for androgenetic alopecia using curcumin-primed milk-derived extracellular vesicles in a mouse model, finding that these vesicles improved hair follicle health and promoted hair regeneration by modulating key signaling pathways and reducing inflammation.

This study found that oral administration of cedrol, a component of ginger, improved hair regeneration and reduced hair follicle damage in cyclophosphamide-induced alopecia areata in mice more effectively than external administration, by enhancing cytokine expression and modulating key signaling pathways.

This study showed that exosomes from hyaluronic acid-primed induced mesenchymal stem cells promote hair growth by enhancing proliferation and migration of hair follicle dermal papilla cells and modulating key growth factors and signaling pathways, potentially counteracting the effects of DHT-induced hair loss.

This review discusses the role of Wnt/β‐catenin signaling in stem and cancer stem cell maintenance and its involvement in the development and regeneration of various organs, but reports no new experimental results.

This review discusses the role of Wnt signaling in cardiac development and explores attempts to modulate it for improving heart function after ischemic injury, but reports no new experimental results.

This review summarizes the current understanding of Wnt signaling in relation to its roles in tissue regeneration and cancer progression and discusses recent medical advancements targeting this pathway for therapeutic purposes.