HUC-MSC-Exosomes Deliver Let-7b/7f-5p to Dermal Papilla Cells for a Multi-Target Synergistic Treatment of Androgenetic Alopecia
June 2026
in “
Journal of Nanobiotechnology
”
hUC-MSC-exosomes human umbilical cord mesenchymal stem cell-derived exosomes Let-7b-5p Let-7f-5p dermal papilla cells androgenetic alopecia hair follicle transition telogen anagen hair regeneration androgen receptor Wnt/β-catenin pathway TGF-β/Smad pathway DPC apoptosis hair density hair diameter stem cell exosomes hair growth cycle hair thinning hair thickening
Studysummary This study reported that human umbilical cord mesenchymal stem cell-derived exosomes may promote hair regeneration and thickness in androgenic alopecia by modulating cellular pathways in hair growth, including increasing hair density and diameter, as observed in a mouse model and an exploratory clinical trial.
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