Raw Western Blot Scans

April 2025 in “ OPAL (Open@LaTrobe) (La Trobe University) ”

Yu-Cheng Chen (695075), Wei-Cheng Tsai (2292118), Zhi-Xiang Li (21221871), Wan-Jung Lin (247513), Hao-Yu Lin (430067), Yi-Ju Hsieh (557914), Kai-Hsuan Wang (298788), You-Yan Chen (21221874), Tsong-Long Hwang (291514), Tzou-Yien Lin (110829)

human umbilical cord mesenchymal stem cell-derived exosomes UC-MSC-Es human hair dermal papilla cells HHDPCs β-catenin cyclin D1 phosphorylation of Akt GSK-3β PI3K Akt

TLDR Human umbilical cord stem cell exosomes may help treat hair loss by promoting hair cell growth.

This study demonstrates that human umbilical cord mesenchymal stem cell-derived exosomes (UC-MSC-Es) enhance the growth of human hair dermal papilla cells (HHDPCs), which are crucial for hair growth. UC-MSC-Es, characterized by their size (30–180 nm) and specific protein expressions, significantly increased HHDPC populations in the S and G2/M phases and elevated the expression of cell cycle-related proteins, β-catenin, and cyclin D1. The study also found that UC-MSC-Es promote the phosphorylation of Akt and GSK-3β, with the inhibition of PI3K and Akt reducing their proliferative effects. These findings suggest UC-MSC-Es could potentially treat hair loss by modulating PI3K and Akt-dependent pathways in HHDPCs.

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