Dual Effects of HA-iMSC-Exosomes in Human Follicle Dermal Papilla Cells on Androgenic Alopecia in Vitro Model

May 2023

Hyungeun Oh

HA-iMSC-exosomes hyaluronic acid-primed induced mesenchymal stem cells dihydrotestosterone DHT androgenetic alopecia AGA hair follicle dermal papilla cells HFDPC Insulin like growth factor-1 IGF-1 epidermal growth factor EGF transforming growth factor beta1 TGFβ1 interleukin-6 IL-6 androgenic receptor AR Wnt/β-Catenin pathway

TLDR Exosomes from certain stem cells can promote hair growth and counteract hair loss caused by hormones by regulating growth factors and other cellular signals.

The study demonstrates that exosomes from hyaluronic acid-primed induced mesenchymal stem cells (HA-iMSC-exosomes) can counteract the effects of dihydrotestosterone (DHT), a main cause of androgenetic alopecia (AGA), on hair follicle dermal papilla cells (HFDPC). The HA-iMSC-exosomes were found to increase the proliferation and migration of HFDPC, increase the mRNA expression of Insulin like growth factor-1 (IGF-1) and epidermal growth factor (EGF), and decrease the mRNA expression of transforming growth factor beta1 (TGFβ1) and interleukin-6 (IL-6). The HA-iMSC-exosomes also downregulated androgenic receptor (AR) message and restored the Wnt/β-Catenin pathway, which was inhibited by DHT. These findings suggest that HA-iMSC-exosomes can promote hair growth and maintain the anagen phase by regulating growth factors, cytokines, and AR-related Wnt/β-catenin signaling.

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Dual Effects of HA-iMSC-Exosomes in Human Follicle Dermal Papilla Cells on Androgenic Alopecia in Vitro Model