Dual Effects of HA-iMSC-Exosomes in Human Follicle Dermal Papilla Cells on Androgenic Alopecia in Vitro Model
May 2023
New to Epidermal Growth Factor? There is a guide in the encyclopedia. Read the guide → HA-iMSC-exosomes hyaluronic acid-primed induced mesenchymal stem cells dihydrotestosterone DHT androgenetic alopecia AGA hair follicle dermal papilla cells HFDPC Insulin like growth factor-1 IGF-1 epidermal growth factor EGF transforming growth factor beta1 TGFβ1 interleukin-6 IL-6 androgenic receptor AR Wnt/β-Catenin pathway
Studysummary This study showed that exosomes from hyaluronic acid-primed induced mesenchymal stem cells promote hair growth by enhancing proliferation and migration of hair follicle dermal papilla cells and modulating key growth factors and signaling pathways, potentially counteracting the effects of DHT-induced hair loss.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study demonstrates that exosomes from hyaluronic acid-primed induced mesenchymal stem cells (HA-iMSC-exosomes) can counteract the effects of dihydrotestosterone (DHT), a main cause of androgenetic alopecia (AGA), on hair follicle dermal papilla cells (HFDPC). The HA-iMSC-exosomes were found to increase the proliferation and migration of HFDPC, increase the mRNA expression of Insulin like growth factor-1 (IGF-1) and epidermal growth factor (EGF), and decrease the mRNA expression of transforming growth factor beta1 (TGFβ1) and interleukin-6 (IL-6). The HA-iMSC-exosomes also downregulated androgenic receptor (AR) message and restored the Wnt/β-Catenin pathway, which was inhibited by DHT. These findings suggest that HA-iMSC-exosomes can promote hair growth and maintain the anagen phase by regulating growth factors, cytokines, and AR-related Wnt/β-catenin signaling.
