Curcumin-Primed Milk-Derived Extracellular Vesicles Remodel Hair Follicle Microenvironment for the Treatment of Androgenetic Alopecia

May 2025 in “ Regenerative Biomaterials ”

Chongchao Hou, Sihua Wang, Zihang Li, Qing Huang, Yang Jiang, Xin Zhou, Rongying Ou, Danyang Li, Yunsheng Xu

curcumin milk-derived extracellular vesicles androgenetic alopecia testosterone Wnt/β-catenin signaling pathway transforming growth factor beta 1 perifollicular inflammation hair follicle cycle hair regeneration Cur-mEVs AGA

TLDR Curcumin-primed milk vesicles may help treat hair loss by promoting hair growth.

The study explores a novel treatment for androgenetic alopecia (AGA) using curcumin-primed milk-derived extracellular vesicles (Cur-mEVs). A mouse model of AGA was developed using high-dose testosterone to simulate the condition. The application of Cur-mEVs was found to remodel the hair follicle microenvironment by activating the Wnt/β-catenin signaling pathway, reducing transforming growth factor beta 1 expression, and alleviating perifollicular inflammation. These changes helped regulate the hair follicle cycle and promote hair regeneration, suggesting that Cur-mEVs could be a promising therapeutic approach for AGA with potential for clinical application.

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