May 2024 in “European Journal of Immunology” This review discusses the potential of targeting Coenzyme A metabolism to restore metabolic balance, reduce chronic inflammation, and enhance immune function, particularly by modulating Vitamin B5 pathways involved in Th17-mediated inflammation and CD8-dependent anti-tumor immunity.
This study observed that, among alopecia areata patients in Fujian, China, lower IgG4 levels and higher IFN-γ levels were statistically significant, suggesting their potential role as biomarkers for the condition and highlighting avenues for future therapeutic developments.
1 citations
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September 2022 in “Journal of dermatological science” This study found that a combination of vitamins in hair care products promoted hair shaft elongation in a mouse model by activating the PlGF/VEGFR-1 signaling pathway.
August 2025 in “International Journal for Vitamin and Nutrition Research” This review highlights the important role of the vitamin B complex in enhancing tissue repair, reducing inflammation, and improving surgical outcomes in plastic and reconstructive procedures by supporting cellular processes such as mitochondrial efficiency, neurotransmitter biosynthesis, and wound healing pathways.
17 citations
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October 2015 in “Medicine and Pharmacy Reports” This article reviews current research on animal models for hair regrowth treatments and reports no new findings; it highlights the need for studies comparing therapy efficiency and long-term safety.
98 citations
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October 2012 in “Dermatologic Clinics” This article reviews the impact of nutritional deficiencies on hair health, detailing how they can cause structural abnormalities, pigmentation changes, or hair loss; it presents no new clinical findings.
53 citations
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March 2003 in “Journal of Investigative Dermatology” This study found that human keratinocytes express a sodium-dependent multivitamin transporter for biotin, pantothenic acid, and lipoic acid, including a highly specific biotin transport component.
50 citations
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November 2010 in “Otolaryngologic Clinics of North America” This review discusses the oral manifestations associated with hematologic conditions and nutritional deficiencies, without presenting new research results; it emphasizes the impact of blood disorders and vitamin deficiencies on oral health.
29 citations
,
December 1989 in “The journal of nutrition/The Journal of nutrition” This study found that intestinal uptake of pantothenic acid in mice was not affected by dietary levels but may increase slightly in late-stage deficiency, though likely not significantly.
14 citations
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April 2000 in “Animal Science/Animal science” This article explores how various nutrients and metabolic processes impact wool and hair follicle function in animals but reports no new experimental findings.
1 citations
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July 2012 in “EFSA journal” This report concludes that no cause and effect relationship has been established between consuming KF2BL20 and maintaining normal hair in healthy adults.
September 2026 in “Repository of the University of Ljubljana (University of Ljubljana)” This study analyzed hair styling mousses on the Slovenian market, finding that their formulations primarily rely on polymers, with no banned ingredients according to European cosmetics regulations.
April 2024 in “International journal of women's health” This review explores adult female acne, focusing on its multifactorial causes, treatment options, and impact on quality of life, but reports no new clinical results.
January 2017 in “Archives of Aesthetic Plastic Surgery” This study reported that using a shampoo and tonic containing horse placental growth factor improved hair thickness and density in postpartum women over three months.
January 1994 in “SÖFW. Seifen, Öle, Fette, Wachse” This article reviews the cosmetic properties of D-panthenol, noting its moisturizing and hair-strengthening effects, but reports no new clinical results.
13 citations
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September 2021 in “Current Issues in Molecular Biology” This study suggests that D-panthenol may promote hair growth by enhancing cell viability, suppressing apoptosis markers, and elongating the anagen phase in human hair follicle cells.
11 citations
,
April 2017 in “Journal of research in pharmacy practice” This study found that the combination of zinc sulfate and calcium pantothenate improved hair density and participant satisfaction in women with hair loss, suggesting its potential as an initial treatment option.
4 citations
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January 2020 in “Frontiers in Physiology” This review discusses molecular signaling pathways and nutritional factors influencing feather growth and regeneration in poultry and offers no new results; the authors suggest these insights may guide strategies for producing superior plumage.
2 citations
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August 2020 in “Clinical, Cosmetic and Investigational Dermatology” This study found that a combination of oral compounds improved metabolic activity, cell viability, and proliferation in hair follicular keratinocytes, with L-cystine playing a key role in protection against oxidative stress.
2 citations
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October 1951 in “Journal of gerontology” This study reported on the excretion levels of pantothenic acid in patients experiencing achromotrichia and alopecia but did not present new clinical results.
1 citations
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April 2022 in “Toxicology and Environmental Health Sciences” This double-blind randomized placebo-controlled study found that a shampoo containing salicylic acid, panthenol, and niacinamide significantly increased hair count and improved hair loss symptoms in alopecia patients over 24 weeks, compared to a placebo, with no abnormal symptoms reported.
1 citations
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July 2012 in “EFSA Journal” The Panel concluded that there is no established cause and effect relationship between the specified vitamin and pumpkin seed oil combination and the maintenance of normal hair in healthy adults.
December 2025 in “Cosmetics” In a laboratory study, researchers found that a novel Bioactive Crosslink Repair Complex improved both the protection and repair of chemically damaged hair, enhancing tensile strength, shine, and cuticle alignment when added to bleaching mixtures and leave-in conditioners.
November 2024 in “Jurnal Biomedika dan Kesehatan” This study explores premature graying of hair, outlining potential causes such as genetic factors, nutritional deficiencies, and autoimmune disorders, and evaluates various management strategies including nutritional supplements, pharmacotherapy, and addressing underlying conditions.
September 2022 in “Journal of The American Academy of Dermatology” This case report describes a 58-year-old woman with telogen effluvium linked to COVID-19 whose hair loss symptoms greatly improved after using a specific hair care routine for 30 days.
August 2021 in “Journal of the American Academy of Dermatology” This study reported that an anti-hair loss shampoo containing six active ingredients activated the Wnt/β-catenin pathway in human hair follicle dermal papilla cells in vitro.
April 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that a shampoo containing a 6-active ingredient complex increased β-Catenin production in human hair follicle dermal papilla cells to levels comparable to Finasteride, suggesting potential for promoting hair growth. It also showed good cleaning efficacy, volume, and shine in a sensorial study.
January 2020 in “Medpulse International Journal of General Medicine/Medpulse International Journal of Medicine” In this study, among 50 patients with premature hair graying, the combination of biotin, zinc, and calcium pantothenate showed no significant efficacy in treating the condition, and the researchers observed associations with other disorders such as anemia, alopecia areata, thyroid disorder, and vitiligo.
This study found that a food supplement containing L-cystine, pantothenic acid, biotin, and millet extract significantly improved hair density and beauty parameters in healthy Japanese women with light diffuse hair loss after three months.
This study assessed the effects of a formulation containing millet extract, wheat germ oil, L-cystine, and calcium pantothenate on women with telogen effluvium using Digital Phototrichogram, but it reports no new results.