Transport of Biotin in Human Keratinocytes

March 2003 in “ Journal of Investigative Dermatology ”

Franziska Grafe, W Wohlrab, Reinhard H.H. Neubert, Matthias Brandsch

biotin keratinocytes sodium-dependent biotin transport HaCaT cells lipoic acid pantothenic acid desthiobiotin biocytin biotin methyl ester Na+-dependent multivitamin transporter pantothenate vitamin B7 vitamin H skin cells sodium-dependent vitamin transport alpha-lipoic acid vitamin B5 biotin precursor biotin ester

TLDR Human skin cells have a high-affinity system for biotin transport, crucial for skin health.

The study investigated biotin transport in human keratinocytes, revealing a sodium-dependent, carrier-mediated process with a significant enhancement in biotin uptake in the presence of sodium ions. It identified a Na+-dependent multivitamin transporter (SMVT) with a preference for pantothenate and a high-affinity transport component specific for biotin. The research demonstrated that biotin uptake was saturable and inhibited by lipoic acid, pantothenic acid, and desthiobiotin, but not by biocytin or biotin methyl ester. Additionally, a distinct high-affinity biotin transport system was identified, suggesting its role in meeting specific physiological demands.

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Transport of Biotin in Human Keratinocytes

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