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Glossary Vitamin D

fat-soluble vitamin essential for calcium absorption and bone health

Vitamin D is a fat-soluble vitamin that is crucial for maintaining healthy bones and teeth by aiding in the absorption of calcium and phosphorus from the gut. It can be obtained through exposure to sunlight, certain foods, and supplements. There are two main forms: vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol), with D3 being more effective at raising blood levels of the vitamin. Deficiency in vitamin D can lead to conditions such as rickets in children and osteomalacia in adults.

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research Mutations in the vitamin D receptor gene in four patients with hereditary 1,25-dihydroxyvitamin D-resistant rickets

24 citations , November 2008 in “Arquivos Brasileiros de Endocrinologia & Metabologia”

In this study, mutations in the vitamin D receptor were identified in Brazilian children with rickets and alopecia, leading to impaired receptor activation and reduced 24-hydroxylase expression.

research Serum vitamin D3 level in patients with female pattern hair loss

23 citations , January 2016 in “International Journal of Trichology”

This study found that women with female pattern hair loss had significantly lower serum Vitamin D3 levels compared to healthy controls.

Vitamin D And The Skin: A Review For Dermatologists

research Vitamina D y la piel. Una revisión para dermatólogos

16 citations , March 2019 in “Actas Dermo-Sifiliográficas”

This review discusses the relationship between vitamin D and various skin diseases but reports no new clinical results, emphasizing the need to assess and correct vitamin D deficiencies.

research Vitamin D and the Skin: A Review for Dermatologists

13 citations , April 2019 in “Actas Dermo-Sifiliográficas”

This review discusses the relationship between vitamin D and various skin diseases, highlighting recent findings on its role and the importance of assessing and correcting vitamin D levels, but reports no new clinical results.

research ¿Son eficaces los suplementos y las vitaminas en el tratamiento de la alopecia androgenética?

July 2025 in “Nutrición clínica y dietética hospitalaria/Nutrición clínica, dietética hospitalaria”

This study reviewed various supplements for treating androgenetic alopecia and found that Serenoa repens shows the strongest evidence for use as a single treatment, while ketoconazole may help as an adjunct. Other supplements like zinc, vitamin D, and biotina are not recommended unless deficiencies exist.

Immunohistochemical Effect of Vitamin E and Valproic Acid on the Development of Epidermis and Hair Follicles

research Efecto Inmunohistoquímico de la Vitamina E y el Ácido Valproico en el Desarrollo de Epidermis y Folículos Pilosos

February 2025 in “International Journal of Morphology”

In this study conducted on mouse fetuses, valproic acid was found to reduce Sonic Hedgehog expression in the skin and hair follicles, but the inclusion of vitamin E helped mitigate this effect, supporting its potential role in managing valproic acid-induced changes.

research Alopecia Areata and Vitamin D3 Deficiency: The Potential of Calcipotriol as a Treatment

January 2025 in “SKIN The Journal of Cutaneous Medicine”

This study suggests that while vitamin D3 deficiency is linked to alopecia areata severity, evidence for the effectiveness of supplementation or topical calcipotriol treatment remains inconsistent and low quality.

research The study of the range and availability of Vitamin D 3 preparations in the pharmaceutical market of Ukraine

January 2024 in “Fitoterapia”

In this study, the analysis of Ukraine's pharmaceutical market from 2020 to 2023 found a large variety of Vitamin D3 preparations, predominantly domestic and synthetic, with capsule forms being common; consumer surveys highlighted that doctor recommendations strongly influenced purchasing decisions.

Vitamin D Supplementation And Its Impacts On Aesthetics

research SUPLEMENTAÇÃO DE VITAMINA D E SEUS IMPACTOS NA ESTÉTICA

October 2023 in “RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218”

This article discusses how vitamin D supplementation impacts human aesthetics and health, with effects varying positively or negatively based on different dermatological conditions.

research A case control study of serum vitamin D levels in alopecia areata

September 2020 in “International Journal of Research in Medical Sciences”

This study found that individuals with alopecia areata had significantly lower serum vitamin D levels compared to healthy controls, but no significant link between vitamin D levels and disease severity was observed.

research Uso actual de la vitamina D en dermatología

January 2019 in “Revista Medicina Cutánea Ibero-Latino-Americana”

This article reviews the influence of vitamin D on various dermatological diseases and suggests that vitamin D supplementation might aid in maintaining skin cell homeostasis; it reports no new clinical results.

research Combined effect of high-dose vitamin A, vitamin E supplementation, and zinc on adult patients with diabetes: A randomized trial

20 citations , June 2020 in “Journal of Advanced Research”

This study found that high-dose vitamin A and E supplementation with zinc may improve glycemic control and beta-cell function in patients with type 2 diabetes, compared to no supplements.

research Intracranial hypertension secondary to low doses of vitamin A

October 2022 in “Deleted Journal”

This case study reports intracranial hypertension in a 60-year-old woman linked to prolonged intake of low-dose Vitamin A from propolis capsules, highlighting a potential risk even at lower dosages.

research Iperplasia Collaterale Nella Oncogenesi Sperimentale Del Ratto: Rilievi in corso di trattamento con Vitamina A

May 1961 in “Tumori Journal”

This study found that vitamin A treatment in rats reduced hyperplastic-dysplastic changes and sebaceous gland hypertrophy associated with 3,4-benzpyrene-induced tumors.

research Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice

1533 citations , October 2008 in “Endocrine reviews”

This research highlights that engineered mice lacking the vitamin D receptor show multiple health issues similar to human vitamin D deficiency, underscoring the widespread impacts of the vitamin D endocrine system.

research The Nuclear Vitamin D Receptor: Biological and Molecular Regulatory Properties Revealed

1308 citations , March 1998 in “Journal of bone and mineral research”

This review discusses the molecular role of the vitamin D receptor in regulating various biological actions such as bone mineralization and reports no new clinical results, highlighting the complexity of vitamin D's function in multiple tissues.

research Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice¹

519 citations , October 1998 in “Endocrinology”

The study found that normalizing mineral ion levels in vitamin D receptor-ablated mice prevented hyperparathyroidism and bone disorders but did not address hair loss, indicating the VDR's role in hair growth.

research Vitamin D Receptor: New Assignments for an Already Busy Receptor

510 citations , August 2006 in “Endocrinology”

This minireview discusses a proposed model of the vitamin D receptor that explains how 1alpha,25(OH)2D3 can mediate both genomic and rapid responses through different ligand shapes and cellular locations, without presenting new research findings.

Deletion of DNA Binding Domain of the Vitamin D Receptor Abrogates Genomic and Nongenomic Functions of Vitamin D

research Deletion of Deoxyribonucleic Acid Binding Domain of the Vitamin D Receptor Abrogates Genomic and Nongenomic Functions of Vitamin D

277 citations , July 2002 in “Molecular Endocrinology”

In this study, homozygous VDR null mutant mice exhibited nonfunctional vitamin D receptors, leading to growth abnormalities and revealing the limited physiological importance of vitamin D pathways outside the classical receptor.

research Vitamin D: More Than a “Bone-a-Fide” Hormone

276 citations , April 2003 in “Molecular endocrinology”

This review explores the diverse physiological roles of the vitamin D endocrine system, discussing current research on receptor structure, transcription details, murine models, and alternative receptors, but reports no new findings.

research Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention

271 citations , September 2008 in “Nutrition reviews”

This study identified new dietary ligands for the human vitamin D receptor, including curcumin and gamma-tocotrienol, which may influence its biological functions.

research Physical and Functional Interaction between the Vitamin D Receptor and Hairless Corepressor, Two Proteins Required for Hair Cycling

215 citations , September 2003 in “Journal of Biological Chemistry”

This study found that the hairless gene product (Hr) suppresses VDR-mediated gene activation by directly interacting with the vitamin D receptor, potentially affecting hair follicle function.