21 citations
,
March 2019 in “Experimental Dermatology” This review discusses the role of perifollicular macrophages in hair growth and suggests targeting them could be relevant for managing hair growth disorders, but reports no new results.
21 citations
,
June 2018 in “Current Opinion in Genetics & Development” This review discusses recent advancements in regenerative medicine, including functional organ regeneration and the creation of mini-organs, and reports no new clinical results.
21 citations
,
July 2004 in “Apmis” This review describes the development of three mouse models using fluorescent proteins to visualize and study angiogenesis in tumors, particularly detailing interactions between tumor cells and the surrounding stroma.
20 citations
,
October 2008 in “Archives of dermatological research” This study found that angiogenin is expressed in human dermal papilla cells, where it might stimulate hair growth by promoting cell proliferation and local skin angiogenesis.
19 citations
,
April 2021 in “Stem Cell Research & Therapy” This study found that transplantation of autologous stromal vascular fraction cells increased skin thickness and improved regeneration when combined with mechanical stretching, without severe adverse events.
18 citations
,
April 2016 in “Molecular Genetics and Genomics” This study suggests that thymosin beta 4 may regulate hair growth by influencing VEGF and MMP-2 levels through the Wnt/β-catenin/Lef-1 signaling pathway in mouse models.
16 citations
,
October 2018 in “Biochemical and Biophysical Research Communications” In this study, sildenafil was found to enhance human dermal papilla cell proliferation and promote hair growth in mice, suggesting potential use in alopecia treatment.
16 citations
,
February 2013 in “Molecular Medicine Reports” This study found that CD34+ cells from adipose tissue may enhance hair morphogenesis and participate in blood vessel formation in reconstituted skin tissues of mice.
16 citations
,
January 2008 in “Acta dermato-venereologica” Vitamin B12 deficiency can cause skin darkening and increased blood vessels, but treatment can improve symptoms.
15 citations
,
June 2020 in “Applied Materials Today” This study found that SA-MS hydrogel released Mo4+ ions which promoted healing of disease-impaired wounds by enhancing cell proliferation and angiogenesis, and through its photothermal effects addressed skin cancer-impaired wounds in mice.
15 citations
,
December 2011 in “Journal of the European Academy of Dermatology and Venereology” In this study, severe diffuse hair loss in patients with systemic lupus erythematosus was associated with distinct clinical, dermoscopic, and histopathological features, which improved alongside treatment of the underlying condition.
14 citations
,
February 2020 in “Scientific reports” This study found that telocytes in human scalp tissue were located around hair follicles and glands and may be involved in skin regeneration and homeostasis.
14 citations
,
December 2003 in “Medical Hypotheses” This paper proposes a new hypothesis that androgenic hair loss may be caused by changes in scalp vasculature due to androgen effects, but reports no new experimental results.
13 citations
,
November 2021 in “Frontiers in Immunology” This research reported that melatonin may serve as a potential treatment for both rosacea and Alzheimer's disease by regulating inflammation and vascular signaling pathways, demonstrating effectiveness in reducing symptoms associated with rosacea-like skin lesions in experimental settings.
13 citations
,
January 2015 in “Stem cells international” This article reviews the complex roles and therapeutic potential of Mesenchymal Stem Cells across various medical applications, emphasizing their anti-inflammatory and tissue repair functions rather than cell replacement or differentiation, and concludes that more precise measurement of their survival and effectiveness is needed.
13 citations
,
July 2014 in “The Journal of Dermatology” Dermoscopy helped diagnose discoid lupus erythematosus in two patients without needing skin biopsies.
12 citations
,
January 1994 in “PubMed” This study found that elastic fibre arrangements in the skin of domesticated mammals vary with hair density, with densely-haired species having horizontal fibres and sparsely-haired ones exhibiting a sponge-like system.
10 citations
,
February 2022 in “JEADV Clinical Practice” This study suggests that dermoscopy can help identify and distinguish various rosacea subtypes, improving clinical diagnosis and treatment decisions.
9 citations
,
October 1976 in “Journal of Cutaneous Pathology” This study observed that human growth hormone treatment in osteoporosis patients appeared to improve skin thickness and restore dermal structures towards normal without stimulating hair, sebum, or melanin.
8 citations
,
April 2023 in “Advanced materials” In this study, implantable vascularized engineered thrombi using autologous whole blood improved skin wound healing in rats by promoting robust microcapillary networks and accelerating healing processes.
8 citations
,
February 2021 in “Journal of Clinical Medicine” This study found that mesenchymal stem cells sourced from hair follicle outer root sheath showed higher differentiation efficiency and angiogenic potential for vascular graft applications compared to adipose-derived stem cells.
8 citations
,
April 2020 in “Journal of Ethnopharmacology” This review assessed experimental studies on herbs used for alopecia, identifying potential mechanisms involving hair cycle management and keratinocyte processes, but highlighted a need for improved evidence on quality control and toxicity of these herbal treatments.
8 citations
,
February 2016 in “The American Journal of Dermatopathology” In this study, the researchers found that transplanted hair follicles undergo significant morphological changes, including a thickened dermal sheath and increased hair shaft diameter, which are associated with altered follicular vascularization.
8 citations
,
January 2016 in “Journal of Veterinary Medical Science” This study found that canine adipose-derived mesenchymal stem cell-derived dermal papilla-like tissues promoted new hair follicle formation and increased vascularization in mice, suggesting potential for hair regeneration.
8 citations
,
January 2013 in “BioMed Research International” This study observed that both Factor XIIIa+ dermal dendrocytes and microvasculature size decreased with scalp aging and that alopecia changes resembled stress-induced premature senescence.
7 citations
,
April 2023 in “Frontiers in Surgery” This study found that a single dose of 1 mg/kg dexamethasone promoted wound healing in septic mice but delayed it in normal mice.
7 citations
,
July 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” This study demonstrated that human skin can be efficiently reinnervated using human induced pluripotent stem cell-derived neural stem cells, promoting skin vitality and sensory reinnervation comparable to physiological conditions.
7 citations
,
March 2020 in “Journal of King Saud University. Science/Maǧallaẗ ǧāmiʹaẗ al-malik Saʹūd. al-ʹUlūm” This study found that AiQingHua oil improved microcirculation and promoted hair regeneration in mice with testosterone-induced alopecia.
7 citations
,
January 2009 in “International Journal of Trichology” In this study, researchers found that dermoscopy does not provide distinguishing features for diagnosing scalp contact dermatitis from topical minoxidil compared to other causes of severe scalp itching.
6 citations
,
January 2023 in “npj regenerative medicine” This study found that transplanting hair follicles into human scars may remodel fibrotic tissue and reduce scarring by altering collagen structure and decreasing pro-fibrotic factors.