Participation of CD34-Enriched Mouse Adipose Cells in Hair Morphogenesis

February 2013 in “ Molecular Medicine Reports ”

Jing He, Huichuan Duan, Yao Xiong, Wenjie Zhang, Guangdong Zhou, Yilin Cao, Wei Liu

TLDR CD34+ cells from fat tissue help form hair follicles and blood vessels in skin.

The study investigated the role of CD34+ cells, enriched from adipose tissue, in hair morphogenesis using a model involving GFP transgenic mice. CD34+ cells, when mixed with fetal mouse keratinocytes and dermal fibroblasts, were found to contribute significantly to the development of hair follicles in reconstituted skin tissue, unlike CD34- cells. Histological and immunofluorescent analyses indicated that CD34+ cells integrated into dermal sheath structures, suggesting their specific involvement in hair morphogenesis. Additionally, CD34+ and SVF cells participated in blood vessel formation, but only CD34+ cells showed a strong potential for multiple differentiation, highlighting their role as adipose-derived mesenchymal stem cells (ADMSCs) with enhanced capabilities in skin development.

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Research cited in this study

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