TLDR CD34+ cells from fat tissue help form hair follicles and blood vessels in skin.
The study explored the involvement of CD34+ cells from mouse adipose tissue in hair follicle morphogenesis, using a model with GFP transgenic mice. CD34+ cells, when mixed with fetal mouse keratinocytes and dermal fibroblasts, significantly contributed to hair follicle formation by integrating into dermal sheath structures, unlike CD34- and unsorted SVF cells. These CD34+ cells also participated in blood vessel formation and demonstrated a strong potential for multi-lineage differentiation, suggesting they could be adipose-derived mesenchymal stem cells (ADMSCs) with enhanced differentiation capabilities. However, they were less potent than bone marrow stem cells in differentiating into multiple skin cell types, indicating differences in differentiation potential among adult stem cell types.
499 citations
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September 2011 in “Cell” Fat-related cells are important for initiating hair growth.
41 citations
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September 2010 in “Journal of dermatological science” Bone marrow and umbilical cord stem cells can help grow new hair.
330 citations
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December 2009 in “Cell stem cell” SKPs are similar to adult skin stem cells and could help in skin repair and hair growth.
58 citations
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April 2009 in “Current stem cell research & therapy” Adult stem cells can become many different cell types, offering wide possibilities for repairing damaged tissues.
201 citations
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August 2006 in “Cell and Tissue Research” 
208 citations
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December 2003 in “Journal of Investigative Dermatology” Certain cells from hair follicles can create new hair and contribute to hair growth when implanted in mice.
158 citations
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May 2003 in “Journal of Investigative Dermatology” Hair growth is influenced by dynamic changes in hair follicle cells, which could help treat hair loss.
745 citations
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February 1992 in “Trends in genetics” Hair follicles create different cell layers and proteins, controlled by various molecules.
88 citations
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July 2019 in “International Journal of Molecular Sciences” Using human fat tissue derived stem cells in micrografts can safely and effectively increase hair density in people with hair loss.
136 citations
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May 2019 in “Cells” Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.
65 citations
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November 2012 in “Tissue Engineering Part B-reviews” Hair follicle stem cells are a promising source for tissue repair and treating skin or hair diseases.
36 citations
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September 2009 in “Journal of Cellular and Molecular Medicine” New treatments targeting skin stem cells show promise for skin repair, anti-aging, and cancer therapy.
Skin stem cells are crucial for maintaining and repairing skin, with potential for treating skin disorders and improving wound healing.
