Mesenchymal Stem Cells: Scientific Support for Multiple Therapies
January 2015
in “
Stem cells international
”
Mesenchymal Stem Cells MSCs bone repair anti-inflammatory factors angiogenic factors insulin-producing cells chondrocytes osteoarthritis low-level laser therapy microvascular pericytes regenerative potential cancer treatment stem cells bone healing inflammation reduction blood vessel growth factors insulin cells cartilage cells arthritis laser therapy pericytes regeneration cancer therapy
TLDR Mesenchymal Stem Cells (MSCs) are promising for multiple therapies, but more research is needed to fully understand and optimize their use.
The document from 2015 discusses the extensive research and clinical applications of Mesenchymal Stem Cells (MSCs), highlighting that over 30,000 papers have been published and over 10,000 patients have been treated with MSCs in over 300 clinical trials. Despite the strong safety record of MSCs, the document acknowledges the need for improved understanding of MSC science and their therapeutic potential. It notes that while MSCs are easy to culture, achieving reproducible assays is challenging. A typical clinical dose of MSCs is 100 million cells, but these diminish rapidly post-injection, raising questions about their therapeutic effects. The issue features seven new works or reviews on MSCs, covering topics such as bone repair, the variability in clinical trial outcomes, the production of anti-inflammatory and angiogenic factors by MSCs, the differentiation of MSCs into insulin-producing cells, the interaction between chondrocytes and MSCs in osteoarthritis, the effects of low-level laser therapy on MSCs, the regenerative potential of microvascular pericytes, and the use of MSCs in cancer treatment. The document underscores the complexity of MSCs and the need for further research to optimize their therapeutic use.
