Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study identified three new mutations in the VDR ligand-binding domain that may cause dysfunction, and noted that oral calcium and calcidol treatment was effective, but only one patient experienced hair growth.

In this study, researchers identified a novel p.R50X mutation in the vitamin D receptor gene, linked to hereditary vitamin D-resistant rickets in two siblings.

In their mouse study, Oda et al. found that removing the MED1 gene in the skin led to hair loss and changes in epidermal cell differentiation, indicating MED1's significant role in these processes.

This study showed that vitamin D receptor gene-deficient rats exhibit hair loss and skin abnormalities due to differences in gene and protein expression patterns, while ligand-independent VDR action is crucial for normal hair cycle maintenance and skin formation.

This review highlights the crucial role of vitamin D signaling in epidermal stem cells during skin wound healing, emphasizing its distinct functions from calcium metabolism and its importance in genomic regulation mediated by the vitamin D receptor.

This study suggests that impaired VDR signaling in mice leads to dysregulated Ddit4 expression, impacting hair cycle progression and wound healing.

This study found that vitamin D regulates cholesterol metabolism and may influence prostate cancer development through mechanisms affecting prostate cell growth and sex hormone metabolism.

This review discusses the role of the mineralocorticoid receptor in skin biology, highlighting its potential involvement in keratinocyte and hair physiology, and proposes it may affect the side effects of glucocorticoid use.

This review summarizes how common polymorphisms in androgen and estrogen receptor genes may influence aging-related symptoms and diseases in men, but it reports no new clinical results.

This review discusses the role of miRNA/mRNA regulatory networks in skin development, epidermal homeostasis, and tissue remodeling, and suggests potential for miRNA-based therapies in treating skin conditions, but reports no new clinical results.

This review discusses the genetic factors involved in hair follicle morphogenesis and cycling and reports no new clinical results; it emphasizes the role of genes in hereditary hair diseases.

This study identified a new cis-regulatory element in the mouse Hr gene that influences its expression in skin and brain cells, highlighting a complex molecular network involved in hair follicle formation.

This review discusses mesenchymal–epithelial interactions in hair follicle development and cycling, highlighting recent insights without reporting new experimental results.

This review discusses the significant role of Wnt signaling in skin development, homeostasis, and disease, highlighting recent advances in understanding its diverse functions, but reports no new experimental results.

This review discusses the role of TGF-β signaling in stem cell recruitment and tissue regeneration, indicating that abnormalities in TGF-β activation contribute to various major diseases and suggesting avenues for therapeutic intervention.

This research discusses how epithelial stem cells in the skin maintain normal homeostasis, contribute to wound repair, and highlights the importance of these processes, as defects can lead to skin diseases including cancers, but provides no new experimental results.

This study found that polycomb-group-mediated repression plays a key role in regulating hair follicle stem cell states and lineage progression by distinct mechanisms in adult mouse skin.

This article discusses the influence of estrogens on hair follicle growth and metabolism, suggesting a significant role alongside androgens in hair growth control but reports no new clinical results.

This review examines apoptotic and anti-apoptotic mechanisms in skin homeostasis and related diseases but presents no new research findings.

This review summarizes recent multidisciplinary advances in sebaceous gland research and highlights potential novel therapeutic strategies for skin diseases, but it reports no new clinical results.

This review discusses the identification and roles of different epidermal stem cell types in skin homeostasis and repair, and reports no new experimental findings.

This review discusses the structure, expression, regulation, and potential roles of NcoA4 in cancer and other pathologies, reporting no new experimental findings.

This review discusses the structure and function of steroid nuclear receptors, particularly focusing on androgen receptor dysregulation in prostate cancer and androgen insensitivity syndromes, without reporting new experimental results.

This study identified an association between the FTO gene and susceptibility to PCOS, providing the first genetic evidence linking PCOS to obesity.

The researchers observed that normal murine hair follicles are direct targets for melatonin, with receptor expression varying throughout the hair cycle, suggesting melatonin's role in hair cycle control.

This study found that hidradenitis suppurativa is associated with increased serum levels of hypoxia-inducible factor-1α, suggesting its role in the disease's pathogenesis and as a treatment target.

This study found that 2MbisP increases epidermal thickening more rapidly than atRA in rhino mice, while both compounds similarly reduce utricle size.

This chapter reviews signaling pathways related to androgenic alopecia in dermal papilla cells of balding human scalps, integrating published information and analysis of molecular interactions, without reporting new clinical results.

This review discusses the complex role of the EDA pathway in vertebrate skeletal development, emphasizing its interaction with other morphogenic pathways to influence skeletal diversity, but reports no new experimental results.

This review discusses the roles of the hairless (HR) protein as a corepressor, particularly its impact on RORα-mediated transcriptional repression, and reports no new experimental findings.