Differential Activity of 2-Methylene-19-Nor Vitamin D Analogs on Growth Factor Gene Expression in Rhino Mouse Skin and Comparison to All-Trans Retinoic Acid

    November 2017 in “ PloS one ”
    Jamie M. Ahrens, James D. Jones, Nirca J. Nieves, Ann M. Mitzey, Hector F. DeLuca, Margaret Clagett‐Dame
    Image of study
    TLDR Some vitamin D analogs can thicken skin and reduce pore size like a common acne treatment, with one analog also affecting skin growth factors.
    The study found that while all tested 2-methylene-19-nor analogs of vitamin D3 increased epidermal thickness in rhino mice, only some reduced utricle size, a process known as comedolysis, similar to the effects of all-trans retinoic acid (atRA). Specifically, the analog 2MbisP was more effective at increasing epidermal thickness rapidly compared to atRA, and both reduced utricle area at the same rate. However, 2MbisP uniquely increased the expression of amphiregulin and epigen mRNA without affecting other epidermal growth factor receptor (EGFR) ligands or the EGFR itself. Another analog, CAGE-3, thickened the epidermis but did not reduce utricle size or significantly affect AREG mRNA levels. These findings suggest that 2MbisP's ability to alter specific EGFR ligand mRNAs may contribute to its effects on epidermal proliferation and comedolysis.
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    6 / 1000+ results

      community hair loss treatment myths that perplex me

      in Treatment  8 upvotes 5 months ago
      Grapefruit juice doesn't significantly affect finasteride or dutasteride. Drinking topical minoxidil is risky; saw palmetto is less effective than finasteride or dutasteride for hair loss.

      community Novel effect of sildenafil (cialis) on hair growth

      in Research/Science  21 upvotes 2 years ago
      Sildenafil (Viagra) shows potential for hair growth by enhancing dermal papilla cell proliferation and stimulating perifollicular vessel formation. Users discuss the possibility of using Cialis (tadalafil) similarly, noting its benefits and side effects.

      community 2 years on treatment (stack update)

      in Progress Pictures  460 upvotes 1 week ago
      A user shared their hair regrowth progress using Dutasteride, topical Minoxidil, Spironolactone, and Estradiol Valerate injections as part of hormone replacement therapy for transitioning. They experienced significant hair improvement and personal satisfaction but caution against this approach for non-transitioning individuals due to irreversible changes.

      community 2.5 mg/ED dut and 1% pyrilutamide, still getting itch?

      in Update  1 upvotes 1 week ago
      The user switched from finasteride to 2.5 mg dutasteride daily and added 1% pyrilutamide to address persistent scalp itch, but the itch remains. They also use 2% ketoconazole and 2.5% selenium sulfide shampoo for temporary relief.

      community 2 months and a half on min + fin

      in Progress Pictures  835 upvotes 1 week ago
      The user has been using topical minoxidil, oral finasteride, and nizoral shampoo for almost three months, along with supplements like biotin and vitamin D3, and reports noticeable hair regrowth without side effects. They aim to have more hair for a wedding in June and are considering using hair fibers for temporary enhancement.

      community 2.5mg Oral Minox per day, Derma roll 1x/week, Ketoconazole Shampoo 3x/week. 2 month progress. Currently have Oral Dut and Min on the way in the mail. We just might make it.

      in Progress Pictures  19 upvotes 1 week ago
      The conversation is about hair loss treatment progress using 2.5mg oral Minoxidil daily, derma rolling weekly, and Ketoconazole shampoo thrice weekly, with plans to add oral Dutasteride. Users discuss the potential benefits and timing of using Dutasteride for hair recovery.

    Similar Research

    5 / 1000+ results