April 2015 in “MOJ Cell Science & Report” This study found that rat hair follicle stem cells can be effectively transfected with VEGF 165 using lentivirus vectors, suggesting their potential use in developing tissue-engineered skin with improved vascularization.
September 2016 in “Journal of Dermatological Science” This study found that extracellular factors from a specific developmental stage can promote hair follicle neogenesis in adult skin by facilitating interactions between fibroblasts and keratinocytes.
26 citations
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April 2012 in “PubMed” In this study, myofibroblasts in rat cutaneous fibrosis were characterized by expressions of vimentin, α-SMA, and Thy-1, and may derive from pericytes or perifollicular dermal sheath cells.
39 citations
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August 2017 in “Annual Review of Genetics” This review discusses recent genetic approaches to understanding tissue regeneration mechanisms in vertebrates and reports no new results; it highlights objectives in identifying cellular and molecular factors involved.
November 2023 in “npj regenerative medicine” This study found that engineered reconstituted skin can form morphogenetic units that promote tissue patterning and hair regeneration, with certain signaling pathways restoring this ability in adult and fetal cells.
This study revealed that during avian skin development, complex tissue architecture results from specific cellular flows and mechanical processes that guide feather bud protrusion and elongation, with distinct differences noted in scale development, where rigidity restricts such transformations.
1 citations
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November 2005 in “Dermatologic Surgery” This study found that aminoguanidine induces VEGF mRNA expression in stored hair follicle micrografts and outer root sheath cells, suggesting potential for enhancing growth factor production during storage.
1 citations
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January 2013 in “China Animal Husbandry & Veterinary Medicine” This study found a strong positive correlation between vascular endothelial growth factor expression and microvessel density in the hair follicles of Liaoning cashmere goats during different fetal periods.
March 2026 in “Frontiers in Cell and Developmental Biology” This review discusses the potential role of vascular endothelial cells as signaling niches influencing epithelial stem cell states in the skin, emphasizing the need for further exploration in this area.
June 2026 in “Journal of Cutaneous and Aesthetic Surgery” This review proposes an anatomy-based framework for understanding recipient site scalp necrosis in hair transplantation, emphasizing regional vascular vulnerability and surgical factors, but does not provide new clinical results.
January 2009 in “International Journal of Pathology and Clinical Medicine” This article reviews the role of VEGF in hair follicle growth and cycle modulation but concludes that its specific molecular mechanisms in hair follicle growth remain unclear.
This case report highlights the successful use of platelet-rich plasma infiltration to treat vasopressin-induced bilateral foot digit gangrene in a 20-year-old female, suggesting its potential in stimulating angiogenesis and wound healing, though further research is necessary to assess its general efficacy.
16 citations
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February 2013 in “Molecular Medicine Reports” This study found that CD34+ cells from adipose tissue may enhance hair morphogenesis and participate in blood vessel formation in reconstituted skin tissues of mice.
March 2026 in “International Journal of Molecular Sciences” In this laboratory study, researchers observed that mouse vascular endothelial cells exhibit dynamic changes after exposure to ionizing radiation, including a transient endothelial subpopulation that facilitates vascular-epidermal communication and skin repair, with shifting roles in angiogenesis and immune surveillance over time.
May 2024 in “Journal of colloid and interface science” This study developed a bilayer bionic skin scaffold that mimics the skin's structure to resist microbial invasion and enhance wound healing, with in vivo animal studies showing improved collagen deposition, neovascularization, and hair follicle formation.
42 citations
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June 2016 in “Developmental Biology” April 2026 in “Biomaterials” 1 citations
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June 2021 in “Problems of Cryobiology and Cryomedicine” In this study on rats, CBF injections demonstrated significant wound healing effects and improved recovery after skin cryoablation, similar to the effects observed with Actovegin.
November 2025 in “ACS Omega” This study found that incorporating Canavalia ensiformis lectin into alginate and carboxymethylcellulose films enhanced angiogenic factor expression, suggesting these biopolymer films could be an effective alternative for wound treatment.
September 2013 in “Science” Human stem cells can aid stroke recovery, research experiences boost students' career aspirations, minoxidil may reduce cancer spread, a molecule can slow tumor growth, a protein affects water flow in cells, magnesium behaves differently at tiny scales, and a new method detects slow-moving objects.
5 citations
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July 2023 in “World Journal of Stem Cells” In a study using a rat model, researchers developed injectable hydrogels from antler reserve mesenchyme which enhanced regenerative healing of full-thickness cutaneous wounds by creating a fetal-like niche that increased stem cell presence and modulated gene expression related to wound healing.
February 2014 in “PubMed” This study reports that high-purity rHFSCs with strong proliferation and high VEGF165 expression can be efficiently obtained, facilitating tissue engineering applications like artificial hair follicles and skin construction.
7 citations
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January 2024 in “Burns & Trauma” This review discusses recent advancements in engineering sebaceous gland organoids for potential regenerative applications, highlighting strategies to create functionalized organoids but reports no new clinical results.
November 2025 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers engineered ventral skin organoids (vSkOs) with specific cellular compositions and signaling environments to generate human amnion-like tissues called Amnioids, offering new tools for studying human development and potential regenerative therapies.
4 citations
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January 2013 in “Genetics and Molecular Research” This study found that VEGF expression and microvessel density in hair follicles of Liaoning cashmere goats follow a bimodal pattern correlated with hair development throughout the year.
21 citations
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December 2017 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that fibroblast behavior switching between proliferation and ECM deposition is vital for dermal architecture, where cell migration is primarily important for tissue repair during wound healing.
135 citations
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January 1996 in “Journal of Investigative Dermatology” 1 citations
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January 2019 in “PubMed” This study found that transgenic mice expressing cgVEGF164 had increased hair follicle diameter and density, potentially linked to higher phosphorylation levels of ERK1/2, AKT1, and LEF1 proteins.
17 citations
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November 2017 in “PLoS ONE” This study observed dynamic behaviors such as cluster formation, migration, and active proliferation of transplanted bone marrow cells in a mouse model, providing insight into cellular-level changes post-transplantation.
January 2011 in “Shiyong kouqiang yixue zazhi” This study found that dermal papilla cells and bulge stem cells can potentially be used to reconstruct hair follicles, as hair follicle-like structures were observed after culturing under a rat's renal capsule.