Temporal Dynamics of Endothelium After Radiation Injury Reveal a Transient Pro-Angiogenic Capillary Subpopulation Associated With Skin Repair
March 2026
in “
International Journal of Molecular Sciences
”
vascular endothelial cells VECs ionizing radiation capillary endothelial subpopulation capVEC2 pro-angiogenic signaling keratinocytes immune surveillance tissue homeostasis pro-inflammatory signaling pro-apoptotic signaling Sp1 regulatory activity vascular-epidermal communication skin repair endothelial cells radiation capillary cells angiogenesis skin cells immune system cell death gene regulation skin healing
Studysummary In this laboratory study, researchers observed that mouse vascular endothelial cells exhibit dynamic changes after exposure to ionizing radiation, including a transient endothelial subpopulation that facilitates vascular-epidermal communication and skin repair, with shifting roles in angiogenesis and immune surveillance over time.
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