Inducing Hair Follicle Neogenesis by Defined Extracellular Factors

The document discusses a study on inducing hair follicle neogenesis using defined extracellular factors. The researchers found that extraction from a specific developmental stage could induce hair follicle neogenesis in adult skin. This process worked by regulating adult fibroblasts to initiate communication with keratinocytes, leading to hair follicle formation. Several extracellular factors were identified as sufficient to initiate this process, suggesting that skin appendage regeneration can be facilitated by creating a pro-regeneration environment with these factors. This approach could potentially be integrated with other methods to enhance functional skin regeneration. The document also mentions a separate study on the development of "squarticles" for targeted delivery of minoxidil to hair follicles and dermal papilla cells, showing improved drug deposition and follicular uptake, as well as a study on the morphological mechanism of pili torti formation in Björnstad syndrome. However, the document does not provide specific numbers of participants or detailed results for these studies.