Role of Vascular Endothelial Growth Factor in Hair Follicle Biology

January 2009 in “ International Journal of Pathology and Clinical Medicine ”

Wei Li

vascular endothelial growth factor VEGF angiogenesis hair follicle dermal papilla cells endothelial cells receptor dimerization autophosphorylation intracellular signaling pathways

TLDR VEGF is important for hair growth and cycle control.

Vascular endothelial growth factor (VEGF) was identified as a crucial regulator of angiogenesis and played a significant role in hair follicle growth and cycle modulation. As an autocrine growth factor in dermal papilla cells, VEGF stimulated hair follicle growth. In endothelial cells, VEGF functioned by binding to its receptor, leading to receptor dimerization, autophosphorylation, and activation of intracellular signaling pathways. However, it remained unclear whether this molecular mechanism was present in hair follicle growth.

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