Role of Vascular Endothelial Growth Factor in Hair Follicle Biology
January 2009
in “
International Journal of Pathology and Clinical Medicine
”
New to Vascular Endothelial Growth Factor? There is a guide in the encyclopedia. Read the guide → Studysummary This article reviews the role of VEGF in hair follicle growth and cycle modulation but concludes that its specific molecular mechanisms in hair follicle growth remain unclear.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
Vascular endothelial growth factor (VEGF) was identified as a crucial regulator of angiogenesis and played a significant role in hair follicle growth and cycle modulation. As an autocrine growth factor in dermal papilla cells, VEGF stimulated hair follicle growth. In endothelial cells, VEGF functioned by binding to its receptor, leading to receptor dimerization, autophosphorylation, and activation of intracellular signaling pathways. However, it remained unclear whether this molecular mechanism was present in hair follicle growth.