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Trichohyalin-like proteins are essential for the development of skin structures like hair, nails, and feathers.

Finasteride, when given in high oral doses to pregnant monkeys, caused genital abnormalities in male fetuses, but not in female fetuses or those exposed to intravenous finasteride.

Mice with too much Claudin-6 have skin barrier problems and abnormal hair growth.

SDF-1/CXCL12 and its receptor CXCR4 are crucial for melanocyte movement in mouse hair follicles.

Hair follicles in mutant mice self-organize into ordered patterns within a week.

Cetaceans lost hair due to changes in the Hr and FGF5 genes.

RXRα is crucial for proper immune response and links diet to immune function.

The document concludes that understanding genetic mutations in the PI3K-AKT-mTOR pathway can lead to better diagnosis and treatment for certain genetic skin disorders.

Muscles can make their own androgens, which may help muscle growth.

Anti-Ro exposed children had more reported neuro-psychiatric issues, but differences from healthy controls were not significant.

BMP signaling is essential for the development of touch domes.

The document says that hirsutism in women usually needs hair removal and hormone treatment to manage symptoms and improve well-being.

MSCs and their exosomes may speed up skin wound healing but need more research for consistent use.

Hair follicle stem cells help maintain skin health and could improve skin replacement therapies.

Boreal caribou in northeastern British Columbia have significant health issues, including infections, tick infestations, and mineral deficiencies.

Loss of Msx2 function causes eye development issues similar to Peters anomaly.

More research is needed on the health effects of hormone therapy for transgender and nonbinary people.

Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

When skin blisters, healing the wound is more important than growing hair, and certain stem cells mainly fix the blisters without helping hair growth.

Integrin β1 is crucial for liver structure and function, preventing fibrosis.

Drinking a lot of alcohol increases the risk of prostate cancer and can worsen the condition.

DNMT1 helps turn hair follicle stem cells into fat cells by blocking a specific microRNA.

Oxidative stress worsens PCOS by damaging cells and disrupting metabolism, suggesting antioxidant treatments might help.

New research shows that skin diversity is influenced by different types of dermal fibroblasts and their development, especially involving the Wnt/β-catenin pathway.

EDA signaling is linked to skin disorders, various cancers, and liver disease.

A new mRNA variant of the SCF gene in sheep skin produces a shorter, different protein.

The guideline refines PCOS diagnosis, promotes a healthy lifestyle, reviews treatments, and stresses long-term follow-up.

Treating non-classic congenital adrenal hyperplasia is complex because the benefits of hormone treatment must be weighed against potential health risks.

Men born very underweight had higher estrogen levels but normal reproduction compared to normal birth weight men.

PCOS causes infertility mainly due to hormonal imbalances, insulin resistance, and chronic inflammation.