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Did you mean Unsaturated Fatty Acids?

Glossary Unsaturated Fatty Acids

contain one or more double bonds in their hydrocarbon chains

Unsaturated fatty acids (UFAs) are a type of fat molecule that contains one or more double bonds between carbon atoms in their hydrocarbon chain. These double bonds create kinks in the chain, preventing the molecules from packing tightly together, which is why unsaturated fats are typically liquid at room temperature. They are considered healthier than saturated fats and are found in foods like olive oil, nuts, and fish.

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research Serum Metabolomics Study of Polycystic Ovary Syndrome Based on Liquid Chromatography–Mass Spectrometry

71 citations , January 2014 in “Journal of Proteome Research”

In this study, distinct metabolic profiles were identified in women with PCOS, suggesting potential biomarkers for diagnosis based on changes in lipid and androgen metabolism.

research Influence of dietary linoleic acid (18:2, n6) on the effects of hyperthyroidism in Mus musculus

January 1992 in “Research Online (University of Wollongong)”

This investigation reviews the potential impact of polyunsaturated fatty acids on thyroid hormone action and does not report new results, highlighting a need for further research on dietary treatment for hyperthyroidism.

research Features of the fatty acid profile of down and guard fibers of felted wool of the Ukrainian Carpathian Mountain sheep breed

July 2026 in “Scientific Reports”

This study found that wool felting in Ukrainian Carpathian Mountain sheep is linked to significant changes in fatty acid composition, particularly highlighting a decrease in 18-methyleicosanoic acid in bound lipids, suggesting it as a potential marker for cuticle lipid layer damage during felting.

research Distribution of Glycolipid and Unsaturated Fatty Acids in Human Hair

18 citations , August 2014 in “Lipids”

This study found that unsaturated fatty acids are more abundant in the cortex of human hair than on its surface, and steryl glycoside-like lipids may help bind the cuticle to the cortex.

research Omega-6 highly unsaturated fatty acids in Leydig cells facilitate male sex hormone production

7 citations , September 2022 in “Communications biology”

This research found that Leydig cells significantly rely on synthesizing omega-6 HUFAs to support male steroid hormone production, highlighting a new role for these fatty acids in the male reproductive system.

research Effect of hair oils and fatty acids on the growth of dermatophytes and their in vitro penetration of human scalp hair.

4 citations , November 1970 in “PubMed”

This study found that mustard oil and unsaturated fatty acids completely suppressed dermatophyte growth and prevented hair penetration at concentrations of 1% and above in Sabouraud's dextrose agar medium.

research Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in primary cicatricial alopecia

14 citations , October 2018 in “PloS one”

In this study, Far2-/- mice were observed to develop focal alopecia with altered sebaceous gland morphology and lower skin lipid levels compared to wildtype mice.

research Metabolomic analysis of amino acids and lipids in human hair altered by dyeing, perming and bleaching

24 citations , April 2016 in “Experimental Dermatology”

This study found that chemical treatments like perming, dyeing, and bleaching significantly alter amino acids and lipids in human hair, which may impact hair strength and quality.

research 5α-Reductase type 1 inhibition of Oryza sativa bran extract prepared by supercritical carbon dioxide fluid

22 citations , August 2011 in “Journal of Supercritical Fluids”

In this study, fraction No. 3 of Oryza sativa bran extract demonstrated high unsaturated fatty acid content and significant 5α-reductase inhibition, suggesting potential for developing anti-androgenic alopecia products.

research Molecular characterization of xerosis cutis: A systematic review

33 citations , December 2021 in “PLoS ONE”

This review summarized multiple molecular markers studied for their association with dry skin, finding considerable variability and uncertainty about which markers best indicate xerosis cutis.

research Inactivation of autophagy leads to changes in sebaceous gland morphology and function

27 citations , July 2018 in “Experimental dermatology”

This study found that autophagy plays a role in sebaceous gland function and sebum composition control in mice lacking the Atg7 gene in keratinocytes.

research Diagnosing Essential Fatty Acid Deficiency

18 citations , June 1998 in “Circulation”

This letter discusses how outdated measurement technology may obscure evidence of essential fatty acid deficiency in low-fat diet patients, potentially leading to undiagnosed EFA insufficiencies related to heart disease.

research The Role of Sebaceous Gland Activity and Scalp Microfloral Metabolism in the Etiology of Seborrheic Dermatitis and Dandruff

241 citations , August 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

This review discusses the roles of sebaceous gland activity, Malassezia yeast, and individual susceptibility in scalp flaking disorders, including dandruff and seborrheic dermatitis, but reports no new experiment results.

research Red ginseng (Panax ginseng Meyer) oil: A comprehensive review of extraction technologies, chemical composition, health benefits, molecular mechanisms, and safety

11 citations , December 2021 in “Journal of Ginseng Research/Journal of ginseng research”

This review discusses the chemical composition, potential health benefits, and extraction methods of red ginseng oil, and reports no new clinical results but emphasizes safety and proposed molecular mechanisms.

research Anti-Hair Loss Potential of Perilla Seed Extracts: In Vitro Molecular Insights from Supercritical Fluid Extraction

July 2025 in “Foods”

In this study, perilla seed extract obtained through supercritical fluid extraction was found to promote hair follicle cell proliferation and downregulate key genes linked to androgenetic alopecia, showing potential as a natural treatment for hair loss in vitro.

research Associations between ionomic profile and metabolic abnormalities in a murine model of sodium sulfide induced alopecia areata

May 2025 in “Frontiers in Pharmacology”

This study investigated alopecia areata in a mouse model, finding that tofacitinib may inhibit disease progression by modulating linoleic acid metabolism and magnesium pathways, particularly affecting CD8+ T cell infiltration in hair follicles, offering insights for potential treatments.

research Optimization of Bear Oil Extraction Process and Hair Growth Activity

March 2024 in “Molecules/Molecules online/Molecules annual”

This study optimized the extraction process of bear grease through enzymatic hydrolysis and found that it was rich in unsaturated fatty acids, enhancing its hair growth-promoting properties in mice compared to traditional methods.

research From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

July 2023 in “Plants”

This review highlights the potential of plant-derived natural compounds as biocompatible and biodegradable materials in dermal and transdermal delivery systems, emphasizing their unexplored benefits and detailing recent advances in isolation techniques and drug delivery technologies.

research Expression and Function of Group IIE Phospholipase A2 in Mouse Skin

26 citations , May 2016 in “Journal of biological chemistry/The Journal of biological chemistry”

This study found that mice lacking sPLA2-IIE had distinct skin abnormalities, particularly affecting hair follicles, highlighting the differing roles of sPLA2 isoforms in mouse skin.

research Human essential fatty acid deficiency: treatment by topical application of linoleic acid.

14 citations , July 1977 in “PubMed”

This study reported that a 19-year-old man's essential fatty acid deficiency was reversed with daily topical application of linoleic acid, improving clinical symptoms and normalizing certain fatty acid levels.

research Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity

47 citations , June 2012 in “Genes & Development”

This study found that maternal consumption of a western diet in mice led to toxic milk production, causing inflammation and alopecia in nursing neonates due to Toll-like-receptor activation.

Anal Involvement in Pemphigus Vulgaris: Study on Recurrence and Treatment Outcomes

research Abstracts Pt.31

February 2006 in “Journal of The American Academy of Dermatology”

This study found that Malassezia globosa, a scalp-associated fungus linked to dandruff, grows with saturated but not unsaturated fatty acids, potentially causing unsaturated fatty acid accumulation on the scalp and triggering dandruff-like flaking in susceptible individuals.

research Bioactive Compounds, Antioxidant Properties, and Cosmetic Applications of Selected Cold-Pressed Plant Oils from Seeds

17 citations , September 2024 in “Cosmetics”

This study assessed the antioxidant properties and contents of carotenoids and chlorophylls in 10 plant oils, finding fenugreek seed oil to be highest in carotenoids and pomegranate oil most active against free radicals, highlighting their potential as natural materials with antioxidant benefits.

research National Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia: Part 2

391 citations , September 2015 in “Journal of Clinical Lipidology”

This document extends previous recommendations by the National Lipid Association for managing dyslipidemia, focusing on lifestyle therapies, special patient groups, and strategies to enhance adherence and patient outcomes.

research Oil in a Commercial Standard Diet Needs Its Product Specifications

2 citations , January 2009 in “Journal of Oleo Science”

In this study, while young rats fed a commercial standard diet with possibly deteriorated oil showed normal growth, they also exhibited liver surface changes and altered serum lipid levels compared to those on a defined diet.

research The Suppression of Very Long Chain Fatty Acids Is Associated with Skin Carcinogenesis

March 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests that the expression of VLCFA biosynthesis genes is suppressed in skin hyperplasia and cancer, which could influence keratinocyte function.

Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane-Induced Dystrophy and Redirect Polyunsaturated Fatty Acid Metabolism Toward β-Oxidation

research Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane Induced Dystrophy and Hijacks Polyunsaturated Fatty Acid Metabolism toward β-Oxidation

19 citations , November 2018 in “Nutrients”

This study reports that polyphenols from Annurca apples may safely promote hair growth and protect against chemotherapy-induced alopecia without interfering with chemotherapy regimens.

research GC-MS Fatty Acid Profile and In silico Studies of Telfairia occidentalis Hook f. (Fluted Pumpkin) and Sphenostylis stenocarpa (African Yam bean) Seeds Oil on Human 5 Alpha Reductase II

February 2026

This study suggests that 9-Octadecenoic acid (Z)-, 2,3-dihydroxypropyl ester from African Yam bean seeds may inhibit the human 5α-reductase II enzyme, potentially helping manage BPH, although further studies are needed.

Epoxy Fatty Acids and Inhibition of the Soluble Epoxide Hydrolase Selectively Modulate GABA Mediated Neurotransmission to Delay Onset of Seizures

research Epoxy Fatty Acids and Inhibition of the Soluble Epoxide Hydrolase Selectively Modulate GABA Mediated Neurotransmission to Delay Onset of Seizures

60 citations , December 2013 in “PLoS ONE”

The researchers found that inhibiting soluble epoxide hydrolase, either genetically or pharmacologically, delayed the onset of chemically induced seizures related to GABA antagonism in experimental models.

research Fatty acids and related lipid mediators in the regulation of cutaneous inflammation

28 citations , January 2018 in “Biochemical Society Transactions”

This review explores the role of fatty acids and bioactive lipid mediators in skin health and suggests targeting this metabolic network to control inflammation and improve skin conditions, but it reports no new findings.