Associations Between Ionomic Profile and Metabolic Abnormalities in a Murine Model of Sodium Sulfide Induced Alopecia Areata

May 2025 in “ Frontiers in Pharmacology ”

Luning Li, Zhen Sun, Wenxue Sun, You Zhai, Na Ding, Wei Wang

alopecia areata sodium sulfide tofacitinib linoleic acid magnesium unsaturated fatty acids CD8+ T cells hair follicle gut microbiome metabolome autoimmune skin diseases AA JAK inhibitor

From the encyclopedia

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Tofacitinib →

a JAK inhibitor for alopecia areata and other autoimmune conditions

Linoleic Acid →

Studysummary This study investigated alopecia areata in a mouse model, finding that tofacitinib may inhibit disease progression by modulating linoleic acid metabolism and magnesium pathways, particularly affecting CD8+ T cell infiltration in hair follicles, offering insights for potential treatments.

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Research cited in this study

17 / 17 results

research Individual Article: Etiology, Treatment Challenges, and the Role of Scalp and Haircare in Managing Dandruff

1 citations , January 2025 in “Journal of Drugs in Dermatology”

This study reports expert consensus statements emphasizing the importance of focusing on overall scalp and hair health for managing dandruff and seborrheic dermatitis, encouraging a shift in treatment perspectives to improve scalp barrier health and patient outcomes.

research Innovative Strategies for the Discovery of New Drugs Against Alopecia Areata: Taking Aim at the Immune System

12 citations , October 2024 in “Expert Opinion on Drug Discovery”

This review discusses the current state of alopecia areata treatments, noting that while recent advances such as Janus Kinase inhibitors show promise, persistent challenges like limited efficacy, safety concerns, and patient compliance highlight the need for innovative drug discovery and development strategies.

research Alopecia Areata: What's New in the Epidemiology, Comorbidities, and Pathogenesis?

49 citations , October 2023 in “Journal of Dermatological Science”

research Reversing Gray Hair: Inspiring the Development of New Therapies Through Research on Hair Pigmentation and Repigmentation Progress

2 citations , January 2023 in “International journal of biological sciences”

This review discusses the mechanisms of hair repigmentation and reports no clinical results; the authors suggest further research into topical treatments for reversing gray hair.

research How Our Microbiome Influences the Pathogenesis of Alopecia Areata

4 citations , October 2022 in “Genes”

This review discusses the role of cutaneous and intestinal microbiota in the development of alopecia areata, summarizing current literature without reporting new clinical results.

research Lifestyle Factors Involved in the Pathogenesis of Alopecia Areata

16 citations , January 2022 in “International journal of molecular sciences”

This review summarizes the influences of lifestyle factors such as smoking, alcohol, and diet on the pathogenesis of alopecia areata but reports no new clinical results.

research Alopecia Areata: Current Understanding and Management

11 citations , January 2022 in “Journal der Deutschen Dermatologischen Gesellschaft”

This review discusses current and emerging therapies for alopecia areata, highlights the challenges in managing this chronic disease, and emphasizes the importance of addressing its psychosocial impacts; it reports no new clinical results.

research Hair-Growth Promoting Effect and Anti-Inflammatory Mechanism of Ginkgo Biloba Polysaccharides

11 citations , October 2021 in “Carbohydrate Polymers”

In this study, WGBP-A2 polysaccharides from Ginkgo biloba leaves promoted hair growth and altered inflammation markers in alopecia areata mice, suggesting potential therapeutic effects through modulation of inflammation pathways.

research Treatment of Pediatric Alopecia Areata: A Systematic Review

48 citations , April 2021 in “Journal of the American Academy of Dermatology”

This study found that topical corticosteroids are the most supported first-line treatment for pediatric alopecia areata, with contact immunotherapy as the next best option.

research Alopecia Areata: A Review on Diagnosis, Immunological Etiopathogenesis, and Treatment Options

56 citations , January 2021 in “Clinical and Experimental Medicine”

This review highlights the challenges in treating alopecia areata, noting that current therapies often lead to relapse and have uncertain long-term effectiveness; it also points to potential future treatments such as JAK-STAT inhibitors and PRP.

research Dihydrotestosterone Regulates Hair Growth Through the Wnt/β-Catenin Pathway in C57BL/6 Mice and In Vitro Organ Culture

23 citations , January 2020 in “Frontiers in Pharmacology”

In this study, DHT was observed to have varying effects on hair follicle growth and related protein expression depending on concentration, with the Wnt/β-catenin pathway potentially playing a significant role.

research Vitamin D and Alopecia Areata: Possible Roles in Pathogenesis and Potential Implications for Therapy

14 citations , January 2019 in “PubMed”

This review examines the potential roles of vitamin D in the pathogenesis of alopecia areata and suggests that vitamin D analogs like calcipotriol may have therapeutic potential.

research High-Throughput T Cell Receptor Sequencing Identifies Clonally Expanded CD8+ T Cell Populations in Alopecia Areata

46 citations , October 2018 in “JCI insight”

In this study, the researchers found that treatment with the JAK inhibitor tofacitinib in alopecia areata patients may reduce clonal CD8+ T cell expansions but does not eliminate them entirely, which could contribute to disease relapse.