Associations Between Ionomic Profile and Metabolic Abnormalities in a Murine Model of Sodium Sulfide Induced Alopecia Areata

    May 2025 in “ Frontiers in Pharmacology ”
    Luning Li, Zhen Sun, Wenxue Sun … Wei Wang
    Studysummary This study investigated alopecia areata in a mouse model, finding that tofacitinib may inhibit disease progression by modulating linoleic acid metabolism and magnesium pathways, particularly affecting CD8+ T cell infiltration in hair follicles, offering insights for potential treatments.
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    Research cited in this study 17

    1. Individual Article: Etiology, Treatment Challenges, and the Role of Scalp and Haircare in Managing Dandruff Journal of Drugs in Dermatology · 2025
    2. Innovative Strategies for the Discovery of New Drugs Against Alopecia Areata: Taking Aim at the Immune System Expert Opinion on Drug Discovery · 2024
    3. Alopecia Areata: What's New in the Epidemiology, Comorbidities, and Pathogenesis? Journal of Dermatological Science · 2023
    4. Reversing Gray Hair: Inspiring the Development of New Therapies Through Research on Hair Pigmentation and Repigmentation Progress International journal of biological sciences · 2023
    5. How Our Microbiome Influences the Pathogenesis of Alopecia Areata Genes · 2022
    6. Lifestyle Factors Involved in the Pathogenesis of Alopecia Areata International journal of molecular sciences · 2022
    7. Alopecia Areata: Current Understanding and Management Journal der Deutschen Dermatologischen Gesellschaft · 2022
    8. Hair-Growth Promoting Effect and Anti-Inflammatory Mechanism of Ginkgo Biloba Polysaccharides Carbohydrate Polymers · 2021
    9. Treatment of Pediatric Alopecia Areata: A Systematic Review Journal of the American Academy of Dermatology · 2021
    10. Alopecia Areata: A Review on Diagnosis, Immunological Etiopathogenesis, and Treatment Options Clinical and Experimental Medicine · 2021
    11. Dihydrotestosterone Regulates Hair Growth Through the Wnt/β-Catenin Pathway in C57BL/6 Mice and In Vitro Organ Culture Frontiers in Pharmacology · 2020
    12. Vitamin D and Alopecia Areata: Possible Roles in Pathogenesis and Potential Implications for Therapy PubMed · 2019
    13. High-Throughput T Cell Receptor Sequencing Identifies Clonally Expanded CD8+ T Cell Populations in Alopecia Areata JCI insight · 2018
    14. Immune Privilege Collapse And Alopecia Development: Is Stress A Factor Skin Appendage Disorders · 2017
    15. Alopecia Areata: Overview and Insights from January 2018 Journal of The American Academy of Dermatology · 2017
    16. The Role of Lymphocytes in the Development and Treatment of Alopecia Areata Expert Review of Clinical Immunology · 2015
    17. Insulin Resistance Is Increased in Alopecia Areata Patients Cutaneous and Ocular Toxicology · 2012

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