The Suppression of Very Long Chain Fatty Acids Is Associated with Skin Carcinogenesis

    November 2020 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Sukhinder Kaur Cheema, Peter Isesele, Sydney Marchando, Michael G. Edwards, Enrique C. Torchia
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    TLDR Suppressing very long chain fatty acids is linked to skin cancer.
    The study found that suppression of very long chain fatty acids (VLCFA) biosynthesis was linked to skin carcinogenesis. Using mutant p53/RAS mice models, researchers observed downregulation of VLCFA genes like ELOVL4, -5, and -6, and reduced levels of specific fatty acids in hyperplastic skin. Experiments showed that VLCFA and their precursors affected cell viability and morphology in both transformed and primary keratinocytes. Meta-analysis of human and mouse datasets confirmed consistent downregulation of ELOVL expression in skin carcinoma. The findings suggested that VLCFA and ELOVL proteins played a role in skin cancer, highlighting the need for further research into their functions in skin cell growth and differentiation.
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