The Suppression of Very Long Chain Fatty Acids Is Associated with Skin Carcinogenesis

    March 2020 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Sukhinder Kaur Cheema, Peter Isesele, Sydney Marchando, Michael G. Edwards, Enrique C. Torchia
    Image of study
    TLDR Suppressing very long chain fatty acids is linked to skin cancer.
    The study found that suppression of very long chain fatty acids (VLCFA) biosynthesis was linked to skin carcinogenesis. Using mutant p53/RAS mice models, researchers observed downregulation of VLCFA genes like ELOVL4, -5, and -6, and reduced levels of specific fatty acids in hyperplastic skin. Experiments showed that VLCFA and their precursors affected cell viability and morphology in both transformed and primary keratinocytes. Meta-analysis of human and mouse datasets confirmed consistent downregulation of ELOVL expression in skin carcinoma. The findings suggested that VLCFA and ELOVL proteins played a role in skin cancer, highlighting the need for further research into their functions in skin cell growth and differentiation.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  141 upvotes 9 months ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

      community I am actually regrowing my hairline without minoxidil or finasteride (mechanical stimulation)

       128 upvotes 6 years ago
      Regrowing hairline without the use of Minoxidil or Finasteride, and instead using mechanical stimulation such as Derma Roller, Nizoral, Zinc Pyrithione, Scalp Massage, Scalp Exercise, Fish Oil and other topical solutions. It is cautioned that there are risks associated with not using medically-prescribed treatments, but it is suggested to consider mechanical stimulation in addition to those prescribed treatments.

      community Hair Remedies that Don't Work for Anybody Seeking Hair Regrowth

      in Treatment  7 upvotes 4 years ago
      Hair loss treatments discussed include minoxidil, finasteride, and RU58841. Salon products and supplements generally don't work for hair regrowth unless there's a severe nutritional deficiency, while hormonal treatments like estrogen and spironolactone can be effective.

    Similar Research

    5 / 1000+ results