Influence of Dietary Linoleic Acid (18:2, N6) on the Effects of Hyperthyroidism in Mus Musculus

    January 1992 in “ Research Online (University of Wollongong) ”
    Nalini Deshpande
    TLDR Dietary linoleic acid may help reduce hyperthyroidism effects.
    This study, conducted by Nalini Deshpande, was inspired by earlier research indicating that a diet high in full-fat soybean meal could mitigate some physical effects of hyperthyroidism, such as weight loss and hair loss, in rats. However, this diet did not affect the increased oxygen consumption associated with thyroid hormone treatment. Subsequent research suggested that unsaturated fatty acids might inhibit thyroid hormone binding to the nucleus and reduce their binding to plasma proteins, potentially increasing free hormone levels in the plasma. The study aimed to explore whether polyunsaturated fatty acids could influence thyroid hormone action as a potential dietary treatment for hyperthyroidism, a common endocrine disorder.
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