September 2002 in “Dermatologic Surgery” This article offers guidance for hair transplant surgeons on addressing old or poorly executed transplants, focusing on surgical precision and effective use of limited donor hair to enhance cosmetic outcomes.
475 citations
,
October 2006 in “Proceedings of the National Academy of Sciences” This study suggests that folliculin, mutated in Birt–Hogg–Dubé syndrome, and its partner FNIP1 may play a role in energy and nutrient sensing through the AMPK and mTOR pathways.
29 citations
,
June 2015 in “Kidney International” This study developed a kidney-specific knockout mouse model lacking the Flcn gene, which recapitulates human Birt-Hogg-Dubé kidney tumorigenesis and shows that mTOR pathway inhibition with rapamycin can suppress tumor growth.
116 citations
,
April 1986 in “The journal of cell biology/The Journal of cell biology” This study reports that a 190,000 molecular weight protein, identified as trichohyalin, may play a matrix role in the development of inner root sheaths in hair follicles.
17 citations
,
June 1994 in “Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin” Tenascin is present in normal skin and certain skin tumors but not in sebaceous glands or their tumors.
May 2005 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” In this study, transgenic mice with a truncated latent transforming growth factor-beta-binding protein showed reduced keratinocyte proliferation and alterations in the hair cycle due to mis-localization of transforming growth factor-beta.
33 citations
,
June 2007 in “Gene Expression Patterns” This study found that CTIP2 is highly expressed in mouse skin during embryogenesis and adulthood, suggesting it may play a role in skin development and homeostasis.
January 2024 in “Doria (University of Helsinki)” This study found that in mouse pancreatic β-cells, the disruption of keratin filaments due to a specific mutation in keratin 18 resulted in altered GLUT2 localization, with less GLUT2 present on the plasma membrane compared to cells with normal keratin.
52 citations
,
January 2003 in “Journal of Investigative Dermatology” This study found that thrombospondin-1 plays a critical role in hair follicle cycle regulation, with deficiency prolonging follicle growth and overexpression delaying it through antiangiogenic effects.
This article discusses the role of epimorphin as a key morphoregulator for various epithelial cells in tubulogenesis and reports no experimental results on its signaling pathways.
168 citations
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August 2000 in “American Journal of Pathology” This study suggests that fibromodulin may regulate transforming growth factor-β activity during scar formation, influencing the transition from fetal scarless repair to adult scar-forming repair in rats.
6 citations
,
October 2012 in “Journal of Heredity” This study identified the Itpr3 gene as responsible for the tufted hair loss phenotype in the BTBR mouse strain.
40 citations
,
May 2005 in “Journal of Cell Science” In this study, transgenic mice expressing a truncated form of latent transforming growth factor-β-binding protein exhibited altered hair cycles due to increased active transforming growth factor-β, impacting keratinocyte proliferation and hair cycle phases.
May 2006 in “The Journal of Cell Biology” In this study, researchers at Johns Hopkins University found that Keratin 17 plays a signaling role in cell growth during a wound response by aiding mTOR pathway activation, beyond its structural functions.
161 citations
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June 1993 in “Journal of Biological Chemistry” This study suggests that human trichohyalin may function as a flexible rod linking keratin intermediate filaments and as a scaffold protein in hair follicle and epidermis cell envelopes.
27 citations
,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” December 2014 in “Journal of Biomedical Research” In a mouse model of peripheral vascular disease, this study found that recombinant thymosin β4 treatment increased expression levels of certain proteins, promoting angiogenesis.
45 citations
,
August 2009 in “American Journal Of Pathology” Noggin promotes skin tumors by activating certain cell signaling pathways.
13 citations
,
August 1999 in “Journal of Investigative Dermatology” This study found that bikunin is expressed in human keratinocytes and may play a role in regulating keratinocyte function during mitosis or inflammation.
27 citations
,
May 2011 in “Journal of Investigative Dermatology” TCHHL1 is a protein important for hair growth, found in hair follicles.
November 2023 in “Advanced Science” A specific hair protein variant increases the spread of breast cancer and is linked to worse survival rates.
135 citations
,
October 1997 in “Journal of biological chemistry/The Journal of biological chemistry” This study suggests that trichohyalin is modified by peptidyl-arginine deiminase before being cross-linked by TGase 3, allowing the formation of rigid structures in hair follicle cells.
28 citations
,
August 2005 in “Journal of Investigative Dermatology” TG5 helps maintain hair follicle health, while TG3 aids in hair shaft development.
February 2024 in “Journal of medicinal food” This study reports that the β-catenin inhibitor tegatrabetan reduced hair growth and hair follicle numbers in mice, suggesting its potential as a model for developing new hair growth materials.
32 citations
,
March 2014 in “PLOS ONE” This study demonstrates that FMOD deficiency in mice alters TGF-β ligand and receptor expression during wound healing stages, leading to delayed wound closure and increased scar size.
11 citations
,
January 1992 in “PubMed” In this study, the researchers found distinct patterns of TGF-beta 1 and IGF-II expression in pig fetal subcutaneous tissue, suggesting specific regulatory roles in developing adipocytes and muscle tissue.
148 citations
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October 1997 in “Journal of Investigative Dermatology” TGF-β receptors are crucial for hair follicle development.
21 citations
,
December 2015 in “European journal of cell biology” In this study, researchers demonstrated that follicular tight junctions in porcine skin form a barrier to nanoparticle penetration, particularly in upper regions, which supports its use as a model for human skin.
36 citations
,
October 2007 in “Journal of Investigative Dermatology” This study found that overexpression of betacellulin in transgenic mice delayed hair follicle morphogenesis and cycling, increased keratinocyte proliferation, and enhanced wound angiogenesis without affecting wound healing strength.
28 citations
,
July 2007 in “Development” In this study, inactivating the TAF4 subunit of transcription factor TFIID in mouse epidermis disrupted gene expression linked to skin and hair function, and increased tumor risk.