TLDR Tenascin is present in normal skin and certain skin tumors but not in sebaceous glands or their tumors.
The study investigated the expression and distribution of tenascin, an extracellular matrix glycoprotein, in normal human skin and skin appendage tumors using immunohistochemical methods on tissues from 79 patients. In normal skin, tenascin was consistently found around the ductal portion of sweat glands, the lower part of hair follicles, hair bulbs, and blood vessels, but not around sebaceous glands. Tumors originating from sweat glands and hair follicles showed tenascin expression around tumor cell nests, while sebaceous gland tumors did not express tenascin. The expression pattern in tumors generally resembled that in corresponding normal tissues.
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