Faculty Opinions Recommendation of Expression of Truncated Latent TGF-Beta-Binding Protein Modulates TGF-Beta Signaling

May 2005 in “ Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ”

Kristina Downing

latent transforming growth factor-beta-binding protein LTBP transforming growth factor-beta TGF-beta keratinocyte proliferation catagen phase pSmad2/3 hair cycle

TLDR Truncated LTBP-1 disrupts TGF-beta signaling, affecting hair growth.

This study demonstrated the role of latent transforming growth factor-beta binding protein-1 (LTBP-1) in modulating the localization and activity of TGF-beta, particularly in the context of postnatal hair follicle development. Researchers used transgenic mice to show that a truncated LTBP-1 construct, which can bind TGF-beta but not the matrix, competes with wild-type LTBP-1, leading to inappropriate TGF-beta activation. The findings, along with previous results showing increased TGF-beta activity in the absence of fibrillin-1, suggested that LTBPs generally function to control TGF-beta localization and activity.

View this study on archive.connect.h1.co →

Discuss this study in the Community →

Related Community Posts Join

6 / 251 results

community Apart from Finasteride, Minoxidil, and Microneedling what are you doing to reverse balding?

in Treatment 215 upvotes 6 months ago

Various treatments for hair loss include minoxidil injections, finasteride, dutasteride, microneedling, Nizoral shampoo, and supplements like vitamin D and biotin. Additional methods mentioned are red light therapy, scalp massages, lifestyle changes, and hair transplants.

community Stop wasting your time with BS products

in Treatment 412 upvotes 10 months ago

Effective treatments for hair loss include finasteride, dutasteride, RU58841, and minoxidil. Starting treatment early is important, and users discuss different brands, forms, and side effects.

community Is this real chat? Finasteride -> fountain of youth and longevity drug?

in Finasteride/Dutasteride 558 upvotes 3 months ago

Finasteride is discussed as a hair loss treatment with benefits like reduced prostate enlargement and skin aging, but it is not seen as a "fountain of youth." Users report mixed experiences, including side effects like decreased libido and dry eyes.

community Dutasteride Isn't Working? Get a Scalp Biopsy NOW

in Finasteride/Dutasteride 19 upvotes 10 months ago

Dutasteride may not be effective for everyone due to underlying issues, suggesting scalp biopsies for further diagnosis. Users discuss using higher doses of dutasteride, topical treatments, minoxidil, and pyrilutamide for hair loss management.

community Oral minoxidil is not an option anymore

in Minoxidil 42 upvotes 1 year ago

A user can't refill their oral minoxidil prescription due to it being out of stock and is seeking alternative hair loss treatments. Suggestions include finding it at another pharmacy, ordering online, using topical minoxidil orally, and considering finasteride or dutasteride.

community Holy shit. Verteporfin may actually be the cure

in Research/Science 1019 upvotes 2 years ago

The post and conversation discuss Verteporfin's potential as a hair loss treatment. It's shown promise in regrowing hair after transplants and might be effective with microneedling.

Related Research

1 / 1 results

research Faculty Opinions Recommendation of Expression of Truncated Latent TGF-Beta-Binding Protein Modulates TGF-Beta Signaling

May 2005 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Truncated LTBP-1 disrupts TGF-beta signaling, affecting hair growth.