Faculty Opinions Recommendation of Expression of Truncated Latent TGF-Beta-Binding Protein Modulates TGF-Beta Signaling

May 2005 in “ Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ”

Kristina Downing

latent transforming growth factor-beta-binding protein LTBP transforming growth factor-beta TGF-beta keratinocyte proliferation catagen phase pSmad2/3 hair cycle

TLDR Truncated LTBP-1 disrupts TGF-beta signaling, affecting hair growth.

The study investigated the role of latent transforming growth factor-beta-binding protein (LTBP) in modulating transforming growth factor-beta (TGF-beta) availability by using transgenic mice expressing a truncated form of LTBP-1. This truncated form lacked matrix-binding sequences, leading to a hair phenotype characterized by reduced keratinocyte proliferation, a shortened growth phase, and early onset of the catagen phase in the hair cycle. The phenotype was attributed to excess active TGF-beta, as indicated by increased pSmad2/3-positive nuclei in the skin of transgenic mice. The findings suggested that the truncated LTBP-1 competed with the wild-type for binding to latent TGF-beta, causing mis-localization and inappropriate activation of TGF-beta, which prematurely initiated catagen. This highlighted the importance of LTBP interaction in the proper targeting and activation of latent TGF-beta.

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research Faculty Opinions Recommendation of Expression of Truncated Latent TGF-Beta-Binding Protein Modulates TGF-Beta Signaling

May 2005 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Truncated LTBP-1 disrupts TGF-beta signaling, affecting hair growth.