research 5α-Reductase Inhibitors in the Treatment of Androgenetic Alopecia
Finasteride improves hair growth in men with androgenetic alopecia.
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research Synthesis and Actions of 5α-Reduced Metabolites of Testosterone in the Nervous System
Testosterone and its metabolites affect brain functions and could help treat neurological disorders.
research Establishment of Type II 5α-Reductase Over-Expressing Cell Line as an Inhibitor Screening Model
A reliable model for screening type II 5α-reductase inhibitors was created and validated.
research Current Understanding of Androgenetic Alopecia: Part I - Etiopathogenesis
research A Randomized Placebo-Controlled Study on the Effects of Pioglitazone on Cortisol Metabolism in Polycystic Ovary Syndrome
Pioglitazone improved insulin sensitivity and altered cortisol metabolism in PCOS patients.
research 5α-Reductase Inhibitors/Finasteride: A Safe and Effective Treatment for Benign Prostatic Hyperplasia
Finasteride is a safe and effective long-term treatment for prostate enlargement, reducing prostate volume and related symptoms.
research 5-Alpha-Dihydrotestosterone Metabolism and Its Relationship with Middle-Phalangeal Hair and Serum Concentrations in Healthy Men
Certain finger length ratios and body hair patterns may predict side effects from birth control pills in women.
research Understanding Curly Hair Mechanics: Fiber Strength
Curly hair is mechanically different from straight hair and may need new testing methods.
research 5-Alpha-Reductase Inhibitors/Finasteride
research Activity of Steroid 4 and Derivatives 4a–4f as Inhibitors of the Enzyme 5α-Reductase Type 1
Compounds 4, 4b, and 4c effectively inhibit an enzyme linked to testosterone conversion without significant toxicity.
research Cardiovascular Safety and Benefits of Testosterone Implant Therapy in Postmenopausal Women: Where Are We?
Testosterone therapy for postmenopausal women appears safe and may protect against heart disease, but requires constant monitoring and more research for long-term effects.
research Targeting JAK/STAT and Wnt/Beta-Catenin Pathways and 5-Alpha-Reductase Activity to Develop an Effective Anti-Hair Loss Product
The lotion with specific plant extracts effectively increased hair growth and improved hair cycle in subjects after 3 months.
research The Interplay Between Finasteride-Induced Androgen Imbalance, Endoplasmic Reticulum Stress, Oxidative Stress, and Liver Disorders in Paternal and Filial Generation
Finasteride in male rats causes liver and metabolic issues in their offspring.
research Effect of Finasteride Treatment in Male Rat: Depressive-Like Behavior and Related Parameters
research Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium
Innate lymphoid cells help control skin bacteria by regulating sebaceous glands.
research Gsdma3 Mutation Causes Bulge Stem Cell Depletion and Alopecia Mediated by Skin Inflammation
A Gsdma3 mutation causes hair loss due to stem cell damage from skin inflammation.
research Hairless Plays a Role in Formation of Inner Root Sheath via Regulation of Dlx3 Gene
Hairless protein affects hair follicle structure by regulating the Dlx3 gene.
research Generation of Comparative Pharmacophoric Model for Steroidal 5α-Reductase I and II Inhibitors: A 3D-QSAR Study on 6-Azasteroids
The study created a model to help design new inhibitors for steroidal 5α-reductase enzymes.
research Hair Growth-Promoting Effect of Resveratrol in Mice, Human Hair Follicles, and Dermal Papilla Cells
Resveratrol may help hair grow, but more research is needed.
research Hair Growth Promotion Effect of Nelumbinis Semen Extract with High Antioxidant Activity
Nelumbinis Semen extract helps hair grow and could prevent hair loss.
research A Homozygous Missense Mutation in the Fibroblast Growth Factor 5 Gene Is Associated with the Long-Hair Trait in Angora Rabbits
A specific gene mutation causes long hair in Angora rabbits.
research Efficacy of Topical Finasteride 0.5% vs 17α-Estradiol 0.05% in the Treatment of Postmenopausal Female Pattern Hair Loss: A Retrospective, Single-Blind Study of 119 Patients
Topical finasteride works faster and better than 17α-estradiol for postmenopausal hair loss.
research Detection of Five Substitution TPO Mutations in Polycystic Ovary Syndrome and Thyroid Hormones Disturbance Patients
Five different TPO gene mutations were found in PCOS patients with thyroid hormone issues.
research Is Dutasteride a Therapeutic Alternative for Amyotrophic Lateral Sclerosis?
Dutasteride, usually used for prostate issues and hair loss, could potentially treat Amyotrophic Lateral Sclerosis (ALS) due to its neuroprotective, antioxidant, and anti-inflammatory properties, but more testing is needed.
research Impaired LEF1 Activation Accelerates iPSC-Derived Keratinocytes Differentiation in Hutchinson-Gilford Progeria Syndrome
Faulty LEF1 activation causes faster skin cell differentiation in premature aging syndrome.
research Development and Optimization of Finasteride-Cinnamon Oil-Loaded Ethanol-Free Microemulsions for Transdermal Delivery
The optimized microemulsion with cinnamon oil effectively delivers finasteride through the skin without damaging hair.
research Hirsutism: A Comprehensive Update of Embryology, Aetiopathogenesis, and Therapeutic Approach
The document concluded that more research is needed to understand how estrogen affects the enzyme involved in hirsutism development.
research The Role of Wood Sterol in Alopecia Induced by High-Fat Diet Through Lipid Metabolism
Wood sterol may help reduce hair loss caused by a high-fat diet.
research Natural Bioactive Compounds as Potential Sources for Alleviation and Treatment of Androgenetic Alopecia: A Research Advance
Natural compounds from Chinese herbs may safely promote hair growth and treat common hair loss.
research 5 Alpha-Reductase Inhibitory Potential of Solanum Nigrum for Alopecia Management
Solanum nigrum may help treat hair loss.