Detection of Five Substitution TPO Mutations in Polycystic Ovary Syndrome and Thyroid Hormones Disturbance Patients

In 2014, a study was conducted on Polycystic Ovary Syndrome (PCOS) patients, revealing the presence of multiple small peripheral cysts and an increase in ovarian volume. The study found that 20.8% of the PCOS patients had hyperthyroidism. The thyroid stimulating hormone-TSH level was significantly higher (17.34±5.12μIU/ml) in 4 PCOS patients with thyroid hormone disturbances compared to PCOS patients without thyroid disturbances or the healthy control group. Additionally, 7 PCOS patients with thyroid hormone disturbances showed lower levels of triiodothyronine-T3 and thyroxine-T4. Molecular analysis detected five substitution thyroid peroxidase genes -TPO mutations in 5 patients with PCOS and thyroid hormone disturbances. Three of these mutations were found in exon 8 and two in exon 9.