Detection of Five Substitution TPO Mutations in Polycystic Ovary Syndrome and Thyroid Hormones Disturbance Patients

    June 2014 in “ مجلة مركز بحوث التقنيات الاحيائية ”
    Mahdi Saber Al-Deresawi, Ali Fadhel Al Najar, Abdul Hussein Moyet Al-Faisal
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    TLDR Five different TPO gene mutations were found in PCOS patients with thyroid hormone issues.
    In 2014, a study was conducted on Polycystic Ovary Syndrome (PCOS) patients, revealing the presence of multiple small peripheral cysts and an increase in ovarian volume. The study found that 20.8% of the PCOS patients had hyperthyroidism. The thyroid stimulating hormone-TSH level was significantly higher (17.34±5.12μIU/ml) in 4 PCOS patients with thyroid hormone disturbances compared to PCOS patients without thyroid disturbances or the healthy control group. Additionally, 7 PCOS patients with thyroid hormone disturbances showed lower levels of triiodothyronine-T3 and thyroxine-T4. Molecular analysis detected five substitution thyroid peroxidase genes -TPO mutations in 5 patients with PCOS and thyroid hormone disturbances. Three of these mutations were found in exon 8 and two in exon 9.
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