Association of Polycystic Ovary Syndrome and Graves' Disease: Is Autoimmunity the Link Between the Two Diseases?

    January 2012 in “ Indian Journal of Endocrinology and Metabolism ”
    Shazia Nisar, Parvez Ahmad Shah, Mohammad Shafi Kuchay, Manzoor A. Bhat, Aafia Rashid, Sajjad Ahmed, Mohd Ashraf Ganie
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    TLDR The document suggests that there might be an autoimmune link between polycystic ovary syndrome and Graves' disease.
    The document from 2012 presents a case series involving six women with an average age of 27.5 years and a mean BMI of 22.73 kg/m², who were diagnosed with both polycystic ovary syndrome (PCOS) and Graves' disease. The women met the AE-PCOS criteria for PCOS and had clinical and biochemical evidence of Graves' disease, with suppressed TSH levels averaging 0.052 μIU/ml. The study suggests a non-coincidental association between the two conditions, potentially linked by autoimmunity, and emphasizes the need for further research to understand the etiopathogenic connection. The authors recommend that clinicians consider PCOS in women with Graves' disease who exhibit reproductive abnormalities even after achieving euthyroidism. The study is limited by its observational cross-sectional nature and calls for prospective longitudinal studies for a deeper investigation.
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