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This study developed 3DEEP, a tissue clearing and spatial transcriptomic method, to map hair follicle development in a single time point from a 12-hour-old mouse, detailing molecular stages, signaling dynamics, and structural changes within developing follicles.

This case report describes an 8 cm giant pilomatricoma on a 67-year-old man's scalp, revealing distinct transcriptional patterns related to hair follicle factors and keratin through spatial gene expression analysis.

This study found that in spiny mice, the proximal side of ear wounds is crucial for regeneration, a process possibly linked to unique injury-induced immune responses compared to nonregenerative rodents.

Light skin shows more inflammation from sun exposure than dark skin.

This study found significant differences in cashmere fiber diameters between two groups of cashmere goats and identified 211 genes and 50 metabolites related to hair follicle growth and cellular functions, suggesting potential pathways to improve cashmere quality.

Discoid lupus erythematosus involves immune activation and fibrosis around hair follicles, with shared pathways across humans, dogs, and mice, suggesting potential treatments for both humans and animals.

Acne involves increased lipid production and inflammation, affecting skin cell behavior and treatment resistance.

This study explored how T cells interact with hair follicles in primary cicatricial alopecias by using spatial transcriptomics across mice, dogs, and human samples, revealing specific communication pathways and potential drug targets like CFD and S100A8/9 for future therapeutic research.

This study details a step-by-step protocol for preparing mammalian skin samples, including hair follicles, for spatial transcriptomics to overcome challenges inherent in applying this technique to the skin.

CD8+ T cells attack hair follicle stem cells, causing scarring and hair loss in Discoid Lupus.

This study suggests that caveolin-1 may be a potential target for treating psoriasis, as its downregulation was linked to psoriasis markers that improved with soluble caveolin scaffolding domain peptide treatment.

This study found that human basal cell and squamous cell carcinomas have distinct gene expression patterns, with specific up-regulation of zinc finger encoding genes in basal cell carcinoma.

This study found that decreased TRPS1 expression in balding dermal papilla cells may impair their signaling ability, contributing to hair follicle miniaturization in androgenic alopecia.

This study identified altered neurological pathways and potential drug targets involved in androgenetic alopecia, suggesting areas for future research and possible therapies.

This study found that Lgr5 and Lgr6 stem cells both activated wound-healing genes, but only Lgr5 stem cells changed their identity to contribute to new skin formation during wound repair.

This study identified 19 specific genes involved in root hair growth and morphogenesis in Arabidopsis, using a combination of computational and experimental methods.

This study characterizes gene expression patterns in embryonic hair follicle progenitors and their niche, identifying signaling pathways like axon guidance that may drive cellular rearrangements for hair follicle formation.

This study found that upper wound fibroblasts are crucial for hair follicle regeneration during wound healing and suggests that these cells, along with papillary fibroblasts, migrate within the wound.

This paper reviews the advancements and applications of single-cell transcriptomics in animal research, highlighting its potential to enhance understanding of animal nutrition, health, genetics, and disease models.

This study found that Super Merino sheep have a higher wool follicle density, finer fleece, and distinct gene expression compared to Small Tail Han sheep, which may inform future breeding and genetic interventions.

This study conducted de novo transcriptome sequencing in sheep skin, identifying and annotating numerous unigenes, which may aid in improving wool quality and understanding hair follicle development.

This study found that numerous genes involved in hair growth, including 73 co-up-regulated ones, were differentially expressed in goat hair follicles during the hair growth cycle.

This perspective highlights how advancements in single-cell sequencing and digital pathology can help understand the complex mechanisms of immune responses, fibrosis, and tissue remodeling related to medical implants, aiming to address the challenges of implant-related tissue reactions reported in this study.

In this study, researchers found that non-invasive analysis of skin surface lipid RNAs revealed alterations in gene expression patterns associated with atopic dermatitis, suggesting its potential for understanding skin disease pathophysiology.

This study used single-cell RNA sequencing to map the cellular composition of sheep hair follicles, revealing differentiation pathways and potential molecular mechanisms for wool curvature, which may inform sheep breeding.

In this study, selenium-rich diets enhanced antioxidant activity in aged mice, suggesting potential biological benefits, although further trials are needed to fully understand long-term risks and benefits.

This study found that targeting IL-6, IL-1, and CCR6 signaling pathways may effectively reduce irradiation-induced alopecia and dermatitis in radiotherapy patients.

This study revealed gene expression patterns in yak hair follicles during different growth phases, enhancing the understanding of cell fate specialization and providing insights for yak villus development.

This study found that brassinosteroid enhances kiwifruit root growth by regulating genes involved in auxin signal transduction, highlighting its critical role in root development.

In this study, whole-genome sequencing of Lanping black-boned sheep identified ERBB4 and ROR1 genes as potentially important in their distinctive hyperpigmentation, enhancing understanding of their genetic evolution from Lanping normal sheep.