38 citations
,
November 2020 in “International journal of biochemistry & cell biology” This review discusses the biological roles and diagnostic significance of keratins in mammalian colon epithelial cells and reports no new clinical results.
29 citations
,
June 2020 in “International Journal of Molecular Sciences” This review discusses the role of Notch signaling in skin diseases such as Hidradenitis Suppurativa and Psoriasis, but reports no new clinical results.
26 citations
,
January 2025 in “iScience” This article reviews the potential applications, benefits, and limitations of platelet-rich plasma in medical practice and reports no new clinical results, emphasizing the need for standardized preparation and treatment protocols.
26 citations
,
September 2024 in “Perspectives in Clinical Research” This article discusses drug repurposing as a strategy to find new uses for existing medications, highlighting its potential benefits like faster development and lower costs, while also addressing challenges such as drug specificity, ethical concerns, and regulatory issues.
26 citations
,
October 2020 in “Biomedicines” This review discusses the applications and potential of Bioengineered Artificial Skin Substitutes in cosmetics and pharmacology research, with no new clinical findings reported.
24 citations
,
January 2011 in “Sexual Development” This study observed that chemically-induced intersex frogs displayed altered brain mRNA profiles, with finasteride increasing certain hormone-related gene expressions and fadrozole reducing aromatase activity without affecting gene transcript levels.
23 citations
,
December 2013 in “Molecular cancer therapeutics” This study found that AR-positive breast cancer cell lines are more sensitive to the dual PI3K/mTOR inhibitor NVP-BEZ235 compared to AR-negative cells.
21 citations
,
June 2023 in “Journal of Nanobiotechnology” This review explores current strategies to enhance extracellular vesicle-based delivery of CRISPR/Cas systems, addressing efficiency challenges and suggesting future directions to bridge gene editing technologies with clinical applications.
21 citations
,
January 2022 in “Biomaterials Science” This article reviews CRISPR/Cas system delivery methods for genome editing and highlights RNA's promise in non-viral in vivo applications but reports no new clinical results.
19 citations
,
December 2023 in “Journal of Investigative Dermatology” In this study, researchers found that the human hair follicle microbiota vary by anatomical compartment and donor age, with specific microbes like S. epidermidis potentially influencing hair follicle functions, which suggests new avenues for therapeutic targeting.
17 citations
,
February 2023 in “Cosmetics” This study explores the use of bioinspired 3D printed hollow microneedles, which may offer improved delivery of anti-wrinkle formulations, and reviews the current landscape and challenges of existing wrinkle treatments and microneedle technology.
16 citations
,
April 2025 in “Foods” This study highlights the diverse applications of *Perilla frutescens* in traditional medicine, cuisine, and industrial settings, noting its significant antioxidant and antimicrobial properties in experimental models, as well as research efforts to enhance its bioactive content and ensure safety and standardization.
14 citations
,
November 2022 in “Development” This review discusses how transposable element activation may hinder tissue regeneration and explores mechanisms to control this activity, reporting no new experimental results.
9 citations
,
May 2025 in “Stem Cell Research & Therapy” This review discusses how extracellular vesicles play a dual role in age-related diseases by contributing to both disease pathogenesis and potential therapeutic strategies through the transfer of specific molecules.
9 citations
,
March 2022 in “Frontiers in Immunology” This review discusses the roles and mechanisms of tissue-resident regulatory T cells in immune regulation and tissue homeostasis, but reports no new experimental results.
9 citations
,
August 2021 in “Experimental dermatology” This review examines the dysregulation of innate immune barriers in the early stages of hidradenitis suppurativa and calls for further research on the role of the hair follicle and immune responses, but reports no new results.
7 citations
,
May 2022 in “Cancers” This study found that UC.145 influences DKK1 methylation and Wnt signaling in gastric cancer, with implications for patient survival and its potential as a predictive biomarker.
6 citations
,
July 2025 in “Advanced Materials” This review discusses cell membrane-coated scaffolds in tissue engineering, emphasizing their potential to enhance therapeutic outcomes in regenerative medicine and reporting no new experimental results.
6 citations
,
September 2024 in “Plant Cell & Environment” This study found that in Arabidopsis root hairs, mild chitosan treatment triggered callose deposition and slowed growth, while a higher concentration inhibited growth without callose deposition, indicating different responses based on chitosan concentration.
6 citations
,
June 2024 in “Medical Review” This review emphasized the significance of biliary fibrosis in hepatobiliary disorders, exploring its clinical manifestations, epidemiology, and cellular factors, and provided insights into current clinical trials and strategies for managing fibrosis-related cholangiopathies.
6 citations
,
November 2022 in “Development” This review discusses the developmental origins and diversity of dermal fibroblasts, focusing on their roles in epidermal and hair follicle growth, but reports no clinical results.
6 citations
,
April 2022 in “Biomedicine & pharmacotherapy” This review discusses the potential of using triads of repositioned medicines targeting multiple pathogenic mechanisms to prevent or delay retina degeneration, but reports no new results.
5 citations
,
November 2024 in “Cells” This review highlighted that in an in vitro setting, 3D spheroid cultures of fish cells offer a promising alternative to traditional monolayer cultures, potentially advancing research in eco-toxicology, immunology, drug screening, and more by better mimicking in vivo conditions.
5 citations
,
June 2024 in “Free Radical Biology and Medicine” This review highlights that current in vitro models often fail to replicate the physiological oxygen levels experienced by different skin cell types, which could affect redox states and functions, potentially accelerating skin aging.
5 citations
,
April 2024 in “Biology” This review explores the current understanding of hair follicle development and regeneration, emphasizing the molecular pathways involved and the potential for bioengineering hair follicles in vitro to advance hair regeneration strategies.
5 citations
,
April 2022 in “Genes” In Angora rabbits, overexpression of miR-129-5p was found to induce apoptosis and inhibit proliferation of dermal papilla cells, highlighting its role in hair follicle development by targeting HOXC13.
4 citations
,
January 2026 in “Micro” This review introduces a framework to integrate bioinspired conductive materials and advanced 3D/4D printing in regenerative medicine for dynamic, responsive tissue regeneration, emphasizing the potential of smart scaffolds to adapt to physiological cues.
4 citations
,
September 2025 in “Pharmaceutics” This review highlights the potential of natural hydrogels as advanced wound dressings, emphasizing their capabilities in mimicking the extracellular matrix, supporting healing, and delivering therapeutic agents for chronic and infected wound care.
4 citations
,
August 2025 in “Molecules” This study highlights the potential of medicinal plants like Rubus vulgaris and Plantago major as sources for skin disorder treatments due to their bioactive compounds' antioxidant, anti-inflammatory, and antimicrobial effects.
4 citations
,
August 2025 in “Journal of Food Science” This review highlights that Tremella fuciformis polysaccharide exhibits various bioactivities, such as antioxidant and immune-modulating effects, and explores its potential applications in food, pharmaceutical, and cosmetic industries.