Biomimetic Cell Membrane-Coated Scaffolds for Enhanced Tissue Regeneration

The document reviews the development and application of biomimetic cell membrane-coated scaffolds (CMCSs) in tissue engineering, emphasizing their potential to enhance tissue regeneration by mimicking native cellular interfaces. CMCSs improve cell adhesion, proliferation, and differentiation, offering advantages such as better immune modulation and resistance to non-specific adhesion. The review highlights various applications, including enhanced insulin secretion, skin regeneration, hair follicle neogenesis, and bone healing, using different cell membrane sources. Challenges like standardizing membrane isolation and ensuring coating stability remain, but the potential of these scaffolds in regenerative medicine is significant. The document also discusses the use of cell membrane coatings in drug delivery systems and introduces bioinspired inverted targeting, where scaffolds attract cells to a treatment site. Overall, cell membrane-inspired strategies are poised to advance regenerative medicine by creating biomimetic environments that closely replicate natural tissues.