Transposon Control as a Checkpoint for Tissue Regeneration

The document hypothesized that the activation of transposable elements (TEs) posed a barrier to tissue repair, which needed to be overcome for successful regeneration. It discussed how uncontrolled TE activity could impede tissue restoration and reviewed mechanisms for controlling TE activity during regeneration. The authors suggested that the diversification and co-evolution of TEs and host control mechanisms might have contributed to the variation in regenerative competency across different tissues and species.