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The safety and effectiveness of gender-affirming treatments for children are uncertain, with potential long-term risks like infertility.

Higher testosterone harms sperm motility, while higher estradiol improves sperm survival.

Gender identity can be more diverse than just male or female.

HNG may help prevent the negative effects of chemotherapy on sperm production and white blood cell counts.

The April 2014 issue of "Fertility and Sterility" discussed various reproductive health topics, including hormone therapy benefits, sperm and genetic factors in male infertility, and the link between PCOS and diabetes.

Active vitamin D3 might protect hair follicles from radiation damage.

Understanding how DHT works is important for diagnosing and treating hormone-related disorders.

Pediatric endocrinologists should provide early fertility counseling and preservation options to young patients at risk of infertility.

Doctors are preparing to potentially perform uterus transplants in transgender women, considering technical, hormonal, and ethical factors.

Some people experience lasting sexual, psychological, and sleep problems after using finasteride or SSRI antidepressants, possibly due to similar underlying causes.

Sex hormones' effects on COVID-19 are unclear and more research is needed to understand their potential as treatment.

Some chemicals in cosmetics may harm pregnant individuals, fetuses, and newborns, and should be avoided unless necessary.

Hormone therapy improves mental well-being in transgender individuals but requires ongoing health monitoring.

Rare ULBP3 gene changes may raise the risk of Alopecia areata, a certain FAS gene deletion could cause a dysfunctional protein in an immune disorder, and having one copy of a specific genetic deletion is okay, but two copies cause sickle cell disease.

N-acetylcysteine may prevent hair loss caused by chemotherapy.

Finasteride is more harmful to male reproductive health than minoxidil.

High doses of rosemary extract can harm the liver, kidneys, and reproductive organs in young rats.

The document concludes that inflammation markers can be used in diabetes, vitamin D3 affects immune pathways, hyperthyroidism changes hormone levels, androgen levels help diagnose Adrenocortical Carcinoma, erectile dysfunction is linked to diabetes, hypogonadism is common in HIV-infected males, and hormones can be biomarkers for various conditions.

A 15-year-old girl with no menstrual period was diagnosed with a genetic condition that makes her body unable to respond to male hormones, leading to female characteristics despite having male genetic makeup.

Congenital Adrenal Hyperplasia is a rare inherited disease causing hormone imbalances, affecting growth, fertility, and heart health, diagnosed through blood tests and treated with medication and lifestyle changes.

A man with both Klinefelter syndrome and primary hyperparathyroidism showed a rare combination of symptoms and genetic patterns.

Finasteride for hair loss increases risk of long-lasting sexual dysfunction.

Cancer can hijack the body's cell repair system to promote tumor growth, and targeting this process may improve cancer treatments.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

New ABCA12 gene mutations were linked to a skin condition with scaling and hair loss, and a treatment helped with hair loss in a related case.

Some parents have a mild form of congenital adrenal hyperplasia without symptoms, and they usually don't need treatment.

Hormone treatment caused hair loss, finasteride helped regrowth.

Some supplements and hormones can increase hair loss by raising DHT levels.

The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.

The document concludes that non-operative treatment for gender dysphoria is safe and effective, and hormone therapy does not increase cancer risk.