December 2023 in “Alzheimer's & dementia” In this rodent study, researchers found that the drug finasteride may reduce anxiety and depression-like behaviors in a model of aging, despite inducing metabolic disturbances and depressive-like behaviors in young rats, suggesting potential considerations for its use in elderly populations.
November 2025 in “BMC Genomics” This study found that the systemic wrinkled skin phenotype in Xiang pigs involves gene expression changes and genetic variations associated with oxidative stress and extracellular matrix components, resembling features seen in Shar-Pei dogs.
December 2025 in “Asian Journal of Advanced Research and Reports” This study found that measuring stress biomarkers in hair could be an effective and simpler method for assessing chronic stress in rats, potentially offering a novel alternative to serum tests with biomarkers including sodium, calcium, and cortisol.
May 2026 in “Research Square”
November 2023 in “European heart journal” In this study, finasteride improved cardiac sympathovagal balance in aging and obese male rats, also enhancing left ventricular function specifically in those modeled for aging, but not affecting healthy rats.
July 2026 in “Archives of Dermatological Research” This study explores the potential of adaptogenic herbal extracts like ashwagandha, rhodiola, and schisandra in treating stress-induced dermatoses, noting their effects on modulating the HPA axis, reducing inflammation, and improving skin barrier function.
October 2025 in “Brazilian Journal of Hair Health” This narrative review identifies telogen effluvium as a growing concern linked to weight-loss interventions, such as GLP-1 receptor agonists and bariatric surgery, attributing hair loss to systemic and metabolic stress rather than permanent hair follicle damage.
December 2025 in “Current Issues in Molecular Biology” In this systematic review, animal studies showed that cytarabine causes multi-organ toxicities, notably neurotoxicity, linked to oxidative stress and other mechanisms, though study quality raises concerns about reliability and translation to human outcomes.
3 citations
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December 2020 in “Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego” In this study, female patients with androgenetic alopecia reported high stress levels, but the type of hair loss treatment did not significantly affect stress alleviation.
24 citations
,
July 1987 in “Dermatologic Clinics” This article reviews various causes of hair loss linked to systemic factors, noting that careful history and examination can lead to accurate diagnosis, but reports no new clinical results.
70 citations
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June 2023 in “International Journal of Molecular Sciences” In this review, researchers explored how air pollutants increase oxidative stress and inflammation in human skin, affect vitamin D synthesis, and interact with the skin microbiota, also discussing AhR/Nrf2 as a potential target for treating pollution-related skin conditions.
10 citations
,
August 2012 in “Current Problems in Pediatric and Adolescent Health Care” This review explores hair signs related to nutrition disorders, such as thin and dyspigmented hair, without presenting new clinical findings; the authors highlight unknowns regarding underlying causes.
March 2026 in “Quality in Sport” This review evaluates photobiomodulation's diverse clinical uses in sports and medicine, reporting physiological modulation and potential therapeutic benefits, but emphasizes the importance of precise dosimetry for success.
March 2026 in “Перспективи та інновації науки” This study reported that visceral massage improved skin elasticity and metabolic indicators such as glucose and lipid levels, suggesting its potential as a non-invasive method for enhancing skin health and systemic metabolism.
22 citations
,
November 2007 in “Journal of Investigative Dermatology Symposium Proceedings” This presentation reviews recent discoveries about signaling mechanisms in hair follicles and their potential influence on hair cycle control and melanogenesis, without presenting new experimental results.
3 citations
,
May 2023 in “Frontiers in Public Health” In this study, 76% of hospitalized COVID-19 patients experienced post-COVID-19 syndrome with symptoms like difficulty concentrating and fatigue lasting around 150 days, significantly impacting their quality of life through increased pain, discomfort, and anxiety.
3 citations
,
August 2022 in “International Journal of Molecular Sciences” This review discusses the increased incidence of hair loss and telogen effluvium among COVID-19 patients and evaluates existing evidence for regenerative treatments like PRP and HFSCs, finding limited published data.
January 2026 in “Phaidra - Repository of the University of Veterinary Medicine, Vienna” In this study, researchers assessed cortisol levels in wolves by comparing hair and fecal samples and found a significant correlation, indicating that hair cortisol accurately reflects systemic levels, but season and body region affect results.
In this preclinical study, PA-011 derived from Periplaneta americana showed significant hair regrowth effects in androgenetic alopecia mouse models by inhibiting inflammation and oxidative stress, activating hair follicle stem cell proliferation, and normalizing skin microbiota, suggesting promise as an AGA treatment.
September 2021 in “CRC Press eBooks” This article describes telogen effluvium as diffuse cyclic hair loss in women caused by systemic stresses, diseases, or physiological situations, but reports no new clinical results.
February 2008 in “Experimental dermatology” This article reviews potential pathomechanisms of vitiligo, emphasizing membrane alterations involving cholesterol and cardiolipin, but reports no new clinical findings.
February 2022 in “Journal of Cosmetic Dermatology” This study suggests that systemic oxidative stress in female pattern hair loss may be related to NRF2 deficiency, and NRF2 activators might assist in treatment.
30 citations
,
November 2012 in “Anais Brasileiros De Dermatologia” This review discusses chronic telogen effluvium and diffuse alopecia areata, providing clinical and diagnostic insights, but presents no new clinical findings.
37 citations
,
October 2014 in “Maturitas” This review discusses the mechanisms and treatment strategies for age-related hair changes, such as androgenetic alopecia and hair graying, and reports no new clinical results.
7 citations
,
October 2019 in “Elsevier eBooks” This chapter defines skin integrity as a blend of intact structural elements and adaptable functional capacity, highlighting its importance in maintaining skin health across various conditions but reports no new research findings.
6 citations
,
November 2024 in “Frontiers in Immunology” This review examines the role of autophagy, specifically macrophage, chaperone-mediated, and microphagy, in the progression of six skin diseases, including psoriasis and systemic lupus erythematosus, illustrating its significance in cellular homeostasis.
6 citations
,
April 2023 in “Cosmetics” In this review, researchers explored the potential of exosomes in cosmetics, skincare, tissue regeneration, and dermatological treatment, noting their promising ability to modulate cellular environments, potentially improving skin health and treating various skin conditions.
2 citations
,
January 2018 in “Elsevier eBooks” This review discusses the complex mechanisms behind acne vulgaris and suggests that dietary modification, along with pro- and prebiotics, may influence its pathogenesis by addressing stress-induced skin inflammation.
1 citations
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August 2025 in “Frontiers in Medicine” This review discusses the roles of microRNAs (miRs) in dermatological diseases and suggests they could be promising targets for innovative skin disease treatments, although further research is needed for clinical application.
1 citations
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December 2022 in “PubMed” This article reviews the potential causes of post-COVID telogen effluvium, attributing it to both inflammatory responses to SARS-CoV-2 and psychosocial stress, and suggests that hair recovery may occur without specific treatment.