Photosensitized 2-Amino-3-Hydroxypyridine-Induced Mitochondrial Apoptosis via Smac/DIABLO in Human Skin Cells

March 2016 in “ Toxicology and applied pharmacology ”

Shruti Goyal, Saroj Kumar Amar, Ashish Dwivedi, Syed Faiz Mujtaba, Hari Narayan Kushwaha, Deepti Chopra, Mahendra Pal, Dhirendra Kumar Singh, Rajnish Kumar Chaturvedi, Ratan Singh Ray

2-Amino-3-hydroxypyridine UV-B radiation reactive oxygen species DNA damage apoptosis mitochondrial release Smac/DIABLO caspase-3 oxidative stress hair follicle progenitor cells A132 UV-B light ROS

TLDR Using A132 hair dye with sunlight can cause skin damage and hair loss.

The study investigated the phototoxic and photogenotoxic effects of the hair dye ingredient 2-Amino-3-hydroxypyridine (A132) under UV-B radiation. It was found that A132 absorbs UV-B light, leading to the formation of reactive oxygen species (ROS) which cause DNA damage and apoptosis in human skin cells. The apoptosis was mediated through the mitochondrial release of Smac/DIABLO and activation of caspase-3. The findings suggested that prolonged use of A132 in hair dyes, combined with sunlight exposure, could increase oxidative stress in the skin, potentially leading to premature hair loss by damaging hair follicle progenitor cells.

View this study on sciencedirect.com →

Discuss this study in the Community →

Similar Research

5 / 1000+ results

research Xenobiotic-Metabolizing Enzymes in the Skin of Rat, Mouse, Pig, Guinea Pig, Man, and in Human Skin Models

38 citations, June 2018 in “Archives of Toxicology”

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

research Stratum Corneum Dysfunction in Dandruff

93 citations, April 2012 in “International Journal of Cosmetic Science”

Improving skin barrier and using antifungal treatments can help manage dandruff.

research Protoporphyrin IX: The Good, the Bad, and the Ugly

138 citations, November 2015 in “Journal of Pharmacology and Experimental Therapeutics”

Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.

Sensitization and Clinically Relevant Allergy to Hair Dyes and Clothes from Black Henna Tattoos: Do People Know the Risk? An Uncommon Serious Case and a Review of the Literature

research Sensitization and Clinically Relevant Allergy to Hair Dyes and Clothes from Black Henna Tattoos: Do People Know the Risk? An Uncommon Serious Case and a Review of the Literature

1 citations, July 2016 in “Cosmetics”

Black henna tattoos can cause severe allergies to hair and textile dyes, and there's a need for greater public awareness and regulation.

research Therapeutics for COVID-19 and Post COVID-19 Complications: An Update

52 citations, January 2022 in “Current Research in Pharmacology and Drug Discovery”

New treatments for COVID-19 show promise, but more effective antiviral drugs are needed.

Photosensitized 2-Amino-3-Hydroxypyridine-Induced Mitochondrial Apoptosis via Smac/DIABLO in Human Skin Cells

Related Community Posts Join

community Does anyone else have experience with Patented Growth Factors (PGF) Treatments / experiences with depression on Fin/Min/Dut?

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

community 2 months progress?? on fin 1mg everyday and derma rolling .5 once a week.

community Just over 2 months on min/fin/derma/niz + vitamins

community Three years + or - on the Big 3. Plus Biotin.