Photosensitized 2-Amino-3-Hydroxypyridine-Induced Mitochondrial Apoptosis via Smac/DIABLO in Human Skin Cells

    April 2016 in “ Toxicology and applied pharmacology ”
    Shruti Goyal, Saroj Kumar Amar, Ashish Dwivedi, Syed Faiz Mujtaba, Hari Narayan Kushwaha, Deepti Chopra, Mahendra Pal, Dhirendra Kumar Singh, Rajnish Kumar Chaturvedi, Ratan Singh Ray
    TLDR Using A132 hair dye with sunlight can cause skin damage and hair loss.
    The study investigated the phototoxic and photogenotoxic effects of the hair dye ingredient 2-Amino-3-hydroxypyridine (A132) under UV-B radiation. It was found that A132 absorbs UV-B light, leading to the formation of reactive oxygen species (ROS) which cause DNA damage and apoptosis in human skin cells. The apoptosis was mediated through the mitochondrial release of Smac/DIABLO and activation of caspase-3. The findings suggested that prolonged use of A132 in hair dyes, combined with sunlight exposure, could increase oxidative stress in the skin, potentially leading to premature hair loss by damaging hair follicle progenitor cells.
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