Pathophysiology of Vitiligo

November 1997 in “ Clinics in dermatology ”

J. Castanet, Jean‐Paul Ortonne

phototherapy narrowband ultraviolet B PUVA topical steroids systemic steroids topical calcineurin inhibitors topical vitamin D analogues surgical treatments narrowband UVB psoralen plus ultraviolet A topical steroids systemic steroids topical calcineurin inhibitors topical vitamin D analogues

TLDR Vitiligo is a skin condition causing white patches, likely due to an autoimmune issue.

The document discussed the pathophysiology of vitiligo, highlighting that the leading theory for its cause was autoimmune in nature. It mentioned that vitiligo could arise from various factors, including genetic, oxidative stress, neural, or viral causes, all contributing to melanocyte destruction and resulting in depigmented lesions. The involvement of CD8+ cytotoxic T cells in melanocyte destruction was emphasized. Treatment approaches included phototherapy (narrowband ultraviolet B and PUVA), topical and systemic steroids, topical calcineurin inhibitors, topical vitamin D analogues, and surgical treatments.

View this study on sciencedirect.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 6 results

community Rare Non responder to Finasteride, Dutasteride, and oral minoxidil

in Minoxidil 78 upvotes 8 months ago

A user did not respond to finasteride, dutasteride, and oral minoxidil for hair loss after four years of treatment and is considering scalp micropigmentation (SMP). Other users suggest the hair loss pattern may indicate alopecia areata and recommend seeing a dermatologist.

community Considering giving a laser comb a shot. Here’s a summary of my research on the subject.

9 upvotes 8 years ago

Considering adding Low Level Laser Therapy (LLLT) to a hair loss prevention regimen; discussing the effectiveness of LLLT, and evaluating double-blind random-controlled trials that have been conducted on laser combs.

community COMPLETE OVERVIEW of the Treatment of androgenetic alopecia in men

26 upvotes 10 years ago

Male androgenetic alopecia is commonly treated with topical minoxidil and oral finasteride, both requiring continuous use. Other options include hair restoration surgery, dutasteride, light therapy, and camouflaging agents.

community A hair model who does beauty ads and has 3 million followers claims he went from almost a Norwood 3 to a perfect hairline in 8 months on only Minoxidil and Rosemary oil. Curious, what are people’s thoughts?

in Chat 1 year ago

This conversation discusses the results of a model who claims he went from almost a Norwood 3 to a perfect hairline in 8 months using only Minoxidil and Rosemary oil. The replies suggest that this could be realistic but long-term results would require additional treatments like finasteride or other medications to prevent further hair loss.

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

in Research/Science 101 upvotes 2 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

community Red Ginseng Extract Promotes the Hair Growth in Cultured Human Hair Follicles

17 upvotes 6 years ago

The conversation is about hair loss treatments, specifically discussing the effectiveness of Red Ginseng Extract in promoting hair growth. Other treatments mentioned include Minoxidil, finasteride, and RU58841.

Related Research

1 / 1 results

research Serum Zinc Concentration in Patients With Alopecia Areata

October 2023 in “Acta dermato-venereologica (Print)”

People with severe hair loss have lower zinc levels in their blood.