Pathophysiology of Vitiligo

November 1997 in “ Clinics in dermatology ”

J. Castanet, Jean‐Paul Ortonne

phototherapy narrowband ultraviolet B PUVA topical steroids systemic steroids topical calcineurin inhibitors topical vitamin D analogues surgical treatments narrowband UVB psoralen plus ultraviolet A topical steroids systemic steroids topical calcineurin inhibitors topical vitamin D analogues

TLDR Vitiligo is a skin condition causing white patches, likely due to an autoimmune issue.

The document discussed the pathophysiology of vitiligo, highlighting that the leading theory for its cause was autoimmune in nature. It mentioned that vitiligo could arise from various factors, including genetic, oxidative stress, neural, or viral causes, all contributing to melanocyte destruction and resulting in depigmented lesions. The involvement of CD8+ cytotoxic T cells in melanocyte destruction was emphasized. Treatment approaches included phototherapy (narrowband ultraviolet B and PUVA), topical and systemic steroids, topical calcineurin inhibitors, topical vitamin D analogues, and surgical treatments.

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research Serum Zinc Concentration in Patients With Alopecia Areata

October 2023 in “Acta dermato-venereologica (Print)”

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