research Living With Lupus Nephritis: Elevated Impact on Patient Life
Lupus nephritis patients face more challenges in family planning, work, symptoms, medication, and quality of life than those without it.
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research Not Always 'Straight Ahead' – A Surprising Cause of Acute Kidney Injury
Hair straightening treatments can cause serious kidney damage, especially if you have skin issues.
research An Integrated Model of Alopecia Areata Biomarkers Highlights Both Th1/Th2 Upregulation, with Stronger Correlations Between Th2 Activation and Disease Severity
Both Th1 and Th2 immune responses are increased in alopecia areata, with Th2 response more strongly linked to how severe the disease is.
research Metabolic disease with autoimmune phenomena: 2 cases of SLE-like disease in young children diagnosed with lysinuric protein intolerance
The document described two cases of young children with lysinuric protein intolerance, a rare metabolic disease, presenting with symptoms resembling systemic lupus erythematosus (SLE). The first case involved a boy with failure to thrive and various symptoms, including hemolytic uremic syndrome-like disease and lupus nephritis, who tested positive for several autoantibodies. The second case was a Turkish girl with polyarthritis, fatigue, diffuse hair loss, and other symptoms, also showing positive autoantibodies. Both children were diagnosed with a lupus-like disease and treated with immunosuppressive therapy. Metabolic studies revealed low serum levels and high urine levels of arginine, lysine, and ornithine, leading to the diagnosis of lysinuric protein intolerance. The second case was confirmed by identifying a new mutation in the SLC7A7 gene.
research Assessment of the Oxidative Stress Status in Androgenetic Alopecia in Egyptian Men
Oxidative stress may contribute to hair loss in Egyptian men.
research Polymeric Micelle Nanocarriers for the Cutaneous Delivery of Tacrolimus: A Targeted Approach for the Treatment of Psoriasis
New micelle nanocarriers deliver Tacrolimus more effectively to skin layers for psoriasis treatment than the current Protopic ointment.
research Systematic Approach to Hair Loss in Women
A systematic approach is crucial for managing hair loss in women.
research Growth Hormone-Responsive Alopecia in Dogs
The exact cause of growth hormone-responsive alopecia in dogs is unclear.
research Pathobiology Questions Raised by Telogen Effluvium and Trichodynia in COVID-19 Patients
COVID-19 may cause hair loss and scalp pain due to inflammation and changes in hair follicle receptors, but these symptoms typically resolve in 2 to 4 months.
research The Safety of Local Hormonal Treatment for Vulvovaginal Atrophy in Women With Estrogen Receptor-Positive Breast Cancer on Adjuvant Aromatase Inhibitor Therapy: Meta-Analysis
Local hormonal treatment for vulvovaginal atrophy is likely safe for women with estrogen receptor-positive breast cancer on aromatase inhibitors.
research Physical Inactivity Is a Disease Synonymous With a Non-Permissive Brain Disorder
Physical inactivity is a primary cause of many human illnesses.
research Case 21-2012
The patient was diagnosed with anorexia nervosa and severe malnutrition, requiring urgent refeeding and monitoring.
research Polymeric Micelle Mediated Follicular Delivery of Spironolactone: Targeting the Mineralocorticoid Receptor to Prevent Glucocorticoid-Induced Activation and Delayed Cutaneous Wound Healing
Using polymeric micelles to deliver spironolactone topically could improve wound healing in skin affected by glucocorticoids.
research Reversal by Interleukin-2 of Alopecia Universalis, Mucocutaneous Candidiasis, and Sexual Impotence in a Patient With Malignant Thymoma
Interleukin-2 treatment improved hair growth, sexual function, and reduced fungal infection in a patient with thymoma-related symptoms.
research Hair Loss
Hair loss has many causes and treatments, and losing some hair daily is normal; proper diagnosis is key, and minoxidil can help treat it.
research A Hairy Fall: Syncope Resulting from Topical Application of Minoxidil
A man fainted and felt unwell after using a strong hair growth product, but got better when he stopped using it.
research Comprehensive Overview of Rheumatology Studies: Ottawa, Ontario, Canada, February 13–16, 2013
The document concludes that various findings in rheumatology offer insights into disease severity, treatment responses, and potential risks in medication, with some limitations due to unspecified participant numbers.
research Response to Effectiveness of Dutasteride in a Large Series of Patients with Frontal Fibrosing Alopecia in Real Clinical Practice
The authors suggest that 5-α-reductase inhibitors, like dutasteride, are effective in treating frontal fibrosing alopecia and should be the first-line treatment, with other options for severe cases. They also recommend further research on Janus kinase inhibitors.
research Significant Effects of Mild Endogenous Hormonal Changes in Humans: Considerations for Low-Dose Testing
Small hormonal imbalances can cause significant health problems, so more sensitive testing for hormone-disrupting chemicals is needed.
research Topical Minoxidil Therapy for Androgenetic Alopecia: A 30-Month Study
Minoxidil solution helps regrow hair in men with hair loss, with most improvement seen at 12 months and effects lasting over 30 months.
research The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome: A Review
Changes in gut bacteria can contribute to the development of Polycystic Ovary Syndrome (PCOS), affecting metabolism, immunity, and causing inflammation. Treatments may involve adjusting these factors.
research S2926 Hepatic Steatosis and Acute Liver Injury in Chronic Arsenic Exposure
This document presents a case of a 29-year-old woman with chronic arsenic exposure leading to hepatic steatosis and acute liver injury. The patient exhibited symptoms such as abdominal pain, nausea, vomiting, and a range of neurological and systemic issues, including polyneuropathy and encephalopathy. Despite initial negative tests for heavy metals, elevated arsenic levels were found in hair and nail samples. The case highlights the association between arsenic toxicity and liver conditions like non-cirrhotic portal fibrosis and non-alcoholic fatty liver disease, emphasizing the importance of recognizing metal toxicity in liver injury diagnosis and management.
research A Cross-Sectional Study of Cutaneous Manifestations in 300 Patients with Diabetes Mellitus
Diabetics most often have skin infections and specific skin conditions related to diabetes.
research Markers of Venous Thromboembolism Risk in Patients with Alopecia Areata: Is There Anything to Worry About?
People with alopecia areata may have a higher risk of blood clots.
research Plain Language Summaries of Various Dermatological Studies
Doctors need more training in skin cancer screening, a new treatment is effective for a skin condition, better diagnosis methods for skin cancer are available, hair loss in women may be linked to hormones and cholesterol, certain skin care products might cause hair loss, babies' skin gets weaker after birth, and a gene mutation might be linked to eczema.
research Evidence or Experience: That Is the Question
The editorial concludes that while evidence-based medicine is crucial, doctors should also use their own experience and consider patient preferences in dermatology care.
research Association of Hypertension and Hyperaldosteronism with Androgenetic Alopecia in Male Patients: Case control study. (Preprint)
This case-control study investigated the association between androgenetic alopecia (AGA), hypertension, and hyperaldosteronism in a Saudi Arabian male population. Involving 20 males with AGA and 20 healthy controls, the study measured blood pressure and serum aldosterone levels. The results showed no significant differences in aldosterone levels, systolic blood pressure, or diastolic blood pressure between the two groups. The findings do not support the hypothesis that AGA is associated with higher risks of hypertension or hyperaldosteronism, aligning with other studies that question this link. Further research is needed to explore the relationship between AGA and systemic health.
research Zinc: An Undervalued Microelement in Research and Treatment
Zinc is important for health and its supplementation may help treat various conditions.
research Thyroid Functions in Patients With Diffuse Hair Loss
Diffuse hair loss in women is often linked to thyroid problems.
research Atrophying Squamous Papulous Dermatitis (Degos Disease): Nine Years of Follow-Up
A woman with Degos disease managed her condition for nine years with medications and had two healthy pregnancies, while a separate finding suggests a possible link between female pattern hair loss and high blood pressure.