Association of mtDNA M/N Haplogroups with Systemic Lupus Erythematosus: A Case-Control Study of Han Chinese Women

    June 2015 in “ Scientific Reports ”
    Youzhou Tang, Li Wang, Min Zhu, Ming Yang, Kuangbiao Zhong, Qing Du, Hao Zhang, Ming Gui
    TLDR The mtDNA N haplogroup is linked to a higher risk of late-onset lupus and specific symptoms in Han Chinese women.
    The study investigated the relationship between mitochondrial DNA haplogroups M and N and systemic lupus erythematosus (SLE) in 868 Han Chinese women with SLE and 870 healthy controls. The N haplogroup was significantly more frequent in patients older than 50 years at onset compared to controls (59.6% vs 41.7%, P = 0.042). The N haplogroup was associated with higher risks for hematological system damage (OR 2.128), skin impairment (OR 1.873), neurological disturbance (OR 3.956), and alopecia (OR 1.322). The findings suggested that the mtDNA N haplogroup was linked to a higher risk of late-onset SLE and specific SLE characteristics in Han Chinese women.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 3 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community It's crazy how it's 2018 and the only hair loss treatments we have feature undesirable side effects and/or aren't even effective for many people.

       134 upvotes 7 years ago
      Hair loss treatments, including minoxidil, dermarolling, finasteride, dutasteride, hair transplants, hair systems, and shaving the head. The conversation covers various opinions on these treatments and mentions possible side effects as well as alternatives like wigs, vitamins, and lifestyle changes. The post expresses disappointment that there has been no major breakthrough in the field of hair loss treatments despite decades of research.

      community Minoxidil doesn’t work over night.

      in Is this regrowth?  196 upvotes 5 months ago
      Minoxidil requires at least 6 months to show results and may not work for everyone. Combining it with Finasteride can improve outcomes, but stopping Minoxidil can result in losing any regrowth.

      community Completely Lost with my hair 20M

      in Progress Pictures  35 upvotes 2 months ago
      A 20-year-old experiencing hair loss uses minoxidil, Nizoral shampoo, vitamin D, and biotin. They are considering finasteride or dutasteride and are advised to consult a doctor for diagnosis and possible oral treatments.

      community Pyrilutamide is literally my only hope

      in Chat  91 upvotes 3 years ago
      Considering treatments for hair loss, including Minoxidil, Finasteride, RU58841, Fluridil and Pyrilutamide. The user is weighing the risks of taking unapproved medication before it has been mass produced.

    Similar Research

    5 / 1000+ results