July 2025 in “Current Stem Cell Research & Therapy” This analysis found that mesenchymal stem cell-derived exosomes show potential as a safe and effective treatment for various skin and subcutaneous tissue diseases.
November 2015 in “Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)” This study concluded that platelet concentrates can promote both soft and hard tissue regeneration, suggesting their potential application in clinical regenerative therapies.
49 citations
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January 2023 in “Gels” This review summarizes recent advancements in three-dimensional bioprinting technology and hydrogel bioinks, highlighting their applications in tissue engineering, but reports no new experimental results.
January 2022 in “SSRN Electronic Journal” This study reports that aging in mice leads to curved hair follicles and an increase in white hairs, potentially due to changes in keratinocyte and melanocyte stem cells.
186 citations
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February 2017 in “Cell Proliferation” This review suggests that omitting the proteolysis step and including tissue pieces in mesenchymal stem cell isolation may improve cell quality, reduce contamination risk, and lower costs and processing time in clinical applications.
28 citations
,
November 2017 in “Molecular and cellular endocrinology” This review examines the roles of testosterone, dihydrotestosterone, and estradiol in activating male sexual behavior in laboratory animals and humans, reporting no new clinical results.
1 citations
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November 2002 in “Journal of dermatology” This study investigated the histogenetic relationship between basal cell carcinoma and hair follicles, revealing specific staining patterns of a monoclonal antibody in different skin tissues.
1 citations
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June 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that fibroblast loss in the upper dermis from UVR exposure is linked to a deregulated inflammatory response, with T cells playing a protective role in fibroblast survival.
This study found that UV radiation-induced fibroblast depletion in the skin is primarily due to a deregulated inflammatory response, with T cells aiding fibroblast survival under stress.
6 citations
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October 2022 in “Journal of cell science” This study re-analyzed single-cell RNAseq data from human and mouse skin, confirming and refining insights into keratin gene regulation during keratinocyte differentiation in epithelial tissues.
April 2017 in “Plastic surgical nursing” Platelet-rich plasma (PRP) is an effective treatment for hair loss that involves scalp injections and requires ongoing maintenance.
April 2009 in “Dermatologic Surgery” The document concludes that the first book on mesotherapy lacks convincing evidence, the second book is good for beginners in facial rejuvenation, and the third book is valuable for understanding complications in skin surgery.
5 citations
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January 2015 in “Dermatology” This report describes a rare case of angiokeratomas on both the upper eyelids and scrotum, adding to the limited literature on eyelid occurrences and discussing potential causes.
January 2019 in “Cell & developmental biology” This study found that using 3D cultures and fetal tissue extracts significantly improved the outcomes of stem cell treatments for regenerative medicine, including hair follicle formation and chronic wound healing.
218 citations
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October 2013 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that removing PPARγ specifically from mouse adipose tissue led to severe fat loss, insulin resistance, diabetes, and associated metabolic abnormalities.
25 citations
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May 2020 in “Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine” This article discusses the potential benefits of platelet-rich plasma injections in ovarian tissue to improve reproductive outcomes in IVF for older individuals and proposes a mechanism to enhance embryo ploidy rescue, but reports no new clinical results.
7 citations
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March 2024 in “Veterinary Medicine and Science” In this study, eight dogs with naturally occurring skin wounds were treated with autologous platelet-rich fibrin therapy, which significantly promoted wound healing and tissue regeneration without using additional medications, leading to promising outcomes and minimal scarring.
This chapter discusses how nanotechnology, through the use of metal nanoparticles and biocompatible carriers, along with antioxidants like curcumin, quercetin, and resveratrol, offers promising approaches for treating PCOS by reducing oxidative stress and inflammation, enhancing insulin sensitivity, and normalizing hormone levels.
This hypothesis paper suggests that sexual and cognitive dysfunctions reported by some men after using finasteride and dutasteride may stem from vascular and tissue changes in penile tissue triggering broader inflammatory effects.
10 citations
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July 2025 in “Stem Cell Research & Therapy” This review summarizes the mechanisms of mesenchymal stem cell-mediated wound healing and highlights engineering strategies that enhance therapeutic outcomes, but it reports no new clinical results.
December 2025 in “IP Indian Journal of Clinical and Experimental Dermatology” This review reports that the treatment of androgenetic alopecia is shifting from single therapies to personalized, multimodal approaches incorporating both traditional and emerging pharmacologics, regenerative strategies, nutraceuticals, cosmeceuticals, and device-based interventions, with combination regimens showing improved outcomes.
5 citations
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October 2020 in “Veterinary record case reports” In this case report, a 15-year-old golden retriever with calcinosis cutis showed accelerated improvement in FLE-treated skin infections compared to untreated areas, highlighting FLE's potential as a treatment adjunct.
119 citations
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January 2014 in “Indian Journal of Dermatology, Venereology and Leprology” This review discusses the use of platelet-rich plasma in various dermatological applications and reports no new clinical results; the authors call for more rigorous trials to confirm its effectiveness.
16 citations
,
December 2006 in “Expert Review of Dermatology” This review discusses the multifaceted roles of hair follicles in skin health, including potential contributions to skin neoplasias, and reports no new results.
14 citations
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April 2019 in “The Ukrainian Biochemical Journal” This study developed a simple method to prepare highly concentrated, resting platelet-rich plasma suitable for cell therapy, effectively preventing clotting while maintaining platelet reactivity and minimizing hemorrhage risk.
7 citations
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January 2025 in “Current Issues in Molecular Biology” This study found that PDRN derived from Lactobacillus rhamnosus showed superior antioxidant and wound-healing properties compared to salmon-derived PDRN, while also offering potential benefits in immune modulation and bioavailability.
1 citations
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January 2014 in “Journal of Cutaneous and Aesthetic Surgery” Regenerative medicine shows promise for aesthetic surgery, but needs more research for widespread use.
1 citations
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January 2009 in “Journal of Dermatology and Venereology” This study found that cells from the upper hair follicle exhibited more active growth compared to other segments in vitro, suggesting their potential as a source of hair follicle stem cells.
March 2026 in “Preprints.org” This study investigated the secretome of adipose mesenchymal stem cells and fibroblasts used in skin care products, finding 16 therapeutic pathways involving numerous signaling mechanisms, which may offer skin benefits through anti-inflammatory and regenerative effects.
April 2025 in “Frontiers in Bioengineering and Biotechnology” This research explores the potential of Gel-SHP hydrogels in tissue regeneration, suggesting they could contribute to new methodologies and understanding in wound healing and dermal shell formation, but results are not detailed.