TLDR A hydrogel made from pig fat helps wounds heal faster by regenerating skin fat cells.
In a 2019 study, researchers found that a hydrogel made from acellular porcine adipose tissue (HAPA), with or without the addition of adipose-derived stem cells (ADSCs), significantly accelerated wound healing in mice. The study, which involved groups of 5 mice at each time point, showed that HAPA promoted the regeneration of intradermal adipocytes, which are important for skin homeostasis and wound healing. The treatment improved fibroblast migration, wound closure, re-epithelialization, angiogenesis, and even led to the regeneration of skin appendages like hair follicles and sebaceous glands. The study, supported by the National Key R&D Program of China and the Youth Innovation Project of Sichuan Medical Research, concluded that HAPA could be a potential biomaterial for soft tissue augmentation and wound healing, with further studies recommended to confirm these findings.
7 citations
,
February 2018 in “Journal of Investigative Dermatology” Fat tissue and a specific protein are crucial for healthy hair growth and maintenance.
22 citations
,
April 2017 in “Cell Stem Cell” Skin wounds can create fat cells that help regenerate hair follicles, with BMP signaling playing a crucial role in this process.
408 citations
,
January 2017 in “Science” Some wound-healing cells can turn into fat cells around new hair growth in mice.
30 citations
,
October 2014 in “Experimental Dermatology” Leptin from skin fat can slow hair growth during certain phases.
77 citations
,
March 2014 in “Cold Spring Harbor Perspectives in Medicine” Fat cells are important for healthy skin, hair growth, and healing, and changes in these cells can affect skin conditions and aging.
1235 citations
,
December 2013 in “Nature” Two fibroblast types shape skin structure and repair differently.
238 citations
,
March 2013 in “Development” Fat cells help recruit healing cells and build skin structure during wound healing.
499 citations
,
September 2011 in “Cell” Fat-related cells are important for initiating hair growth.
November 2023 in “Linköping University medical dissertations” Keratinocytes and adipose-derived stem cells can effectively heal difficult skin wounds.
March 2024 in “Biomedicines” Mesenchymal stem cells show promise for effective skin repair and regeneration.
119 citations
,
March 2020 in “Frontiers in Bioengineering and Biotechnology” Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.
2 citations
,
September 2022 in “Cytotherapy” Fat-derived stem cells show promise for treating skin issues and improving wound healing, but more research is needed to confirm the best way to use them.
27 citations
,
May 2019 in “Jo'jig gonghag gwa jaesaeng uihag/Tissue engineering and regenerative medicine” The best method for urethral reconstruction is using hypoxia-preconditioned stem cells with autologous cells on a vascularized synthetic scaffold.