TLDR CD201+ fascia progenitors are essential for wound healing and could be targeted for treating skin conditions.
The study identifies CD201+ fascia progenitors as crucial players in wound healing, demonstrating their differentiation into proinflammatory fibroblasts and myofibroblasts in a spatiotemporally regulated manner. Using murine models, single-cell transcriptomics, and genetic lineage tracing, the researchers found that retinoic acid (RA) and Hif1a signaling are key checkpoints in this process. RA promotes the proinflammatory state and limits myofibroblast differentiation, while Hif1a facilitates the transition to myofibroblasts, essential for tissue contraction and wound closure. These findings offer potential therapeutic targets for treating impaired wound healing and conditions like keloids and psoriasis.
9 citations,
May 2021 in “Immunological Reviews” Different types of fibroblasts play various roles in kidney repair and aging, and may affect chronic kidney disease outcomes.
48 citations,
June 2020 in “Current Rheumatology Reports” Different types of fibroblasts play various roles in both healthy and diseased tissues, and understanding them better could improve treatments for fibrotic diseases.
1 citations,
February 2023 in “International Journal of Molecular Sciences” The fascial layer is a promising new target for wound healing treatments using biomaterials.
124 citations,
June 2020 in “Cell Stem Cell” Fat cells in the skin help start healing and form important repair cells after injury.
6 citations,
June 2022 in “Frontiers in Bioengineering and Biotechnology” The gel with icariin speeds up wound healing, reduces scarring, and helps hair growth by controlling BMP4 signaling. It also reduces inflammation and improves wound quality in mice, adapts to different wound shapes, and gradually releases icariin to aid healing. It also prevents too much collagen and myofibroblast formation during skin healing.
