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Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

Dihydrotestosterone treatment can help penis growth in boys with 5α-reductase deficiency but doesn't fully normalize size after puberty.

Testosterone and dihydrotestosterone treatments can help with penile growth in males with 5α-reductase type 2 deficiency, with dihydrotestosterone being more effective in infancy.

Androgen treatment with dihydrotestosterone may help maintain height in patients with 5-α-reductase type 2 deficiency, especially before puberty.

Researchers developed a model to predict how well certain compounds can block an enzyme related to hair loss and prostate issues, suggesting a 50 mg dose of finasteride might be effective based on lab and body data.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Gene variant linked to prostate cancer, hormone levels, and hair loss.

A49T gene variant linked to higher prostate cancer risk, lower hormone levels, and slightly reduced balding risk.

5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.

Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Finasteride effectively treats enlarged prostate and male baldness, improves symptoms of hirsutism in women, but doesn't work for acne, and may delay prostate cancer progression with few side effects.

5α-Reductase inhibitors can help treat hair loss, acne, and prostate issues by reducing DHT levels.

Finasteride inhibits enzyme activity in rhesus macaques, suggesting they're useful for evaluating similar drugs.

Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.

Finasteride effectively treats hair loss and enlarged prostate in men, with mild side effects.

Testosterone's muscle-building effects do not require its conversion to DHT.

Dutasteride more effective for hair growth, but has more side effects than finasteride.

Finasteride shows promise for treating hair loss and excessive hair growth, but more research is needed to confirm its effectiveness and safety.

Dihydrotestosterone and 5α-Reductase play a role in hair loss and prostate health, and finasteride can increase hair growth in men without affecting sperm production, but it doesn't work for postmenopausal women with hair loss.

Muscles can make their own androgens, which may help muscle growth.

The exact causes of baldness are not fully understood, limiting treatment options.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

Androgen receptor signaling causes early aging of cells important for hair growth by damaging their DNA.

The gene for slick hair in Senepol cattle is located on chromosome 20 and may involve the SRD5A2 gene.